Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice.

Brain and Behavior
Jana P LimRobert O Messing

Abstract

Although genetic background alters responses to ethanol, there has not yet been a methodical quantification of differences in ethanol-related behaviors between inbred and hybrid mice commonly used in gene-targeting studies. Here, we compared C57BL/6NTac × 129S6/SvEvTac F1 hybrid mice (B6129S6) with C57BL/6NTac inbred mice (B6NT), and C57BL/6J × 129X1/SvJ (B6129X1) and C57BL/6J × 129S4/SvJae F1 hybrids (B6129S4) with C57BL/6J mice (B6J), in five commonly used tests: continuous access two-bottle choice drinking, intermittent limited-access binge drinking, ethanol clearance, ethanol-induced loss of the righting reflex, and conditioned place preference (CPP) for ethanol. We found that inbred B6J and B6NT mice showed greater ethanol preference and consumption than their respective hybrids when ethanol was continuously available. Within the intermittent limited-access drinking procedure, though all lines showed similar intake over eight drinking sessions, the average of all sessions showed that B6NT mice drank significantly more ethanol than B6129S6 mice. In addition, B6J mice consumed more ethanol than B6129X1 mice, although they drank less than B6129S4 mice. No differences in ethanol LORR duration were observed between inbred and h...Continue Reading

References

Sep 1, 1992·Pharmacology, Biochemistry, and Behavior·C L Cunningham, D Noble
Jan 1, 1993·Psychopharmacology·J K BelknapE R Young
Apr 1, 1996·Alcoholism, Clinical and Experimental Research·A A BachmanovG K Beauchamp
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·F A Brook, R L Gardner
Jan 12, 2005·Physiology & Behavior·Justin S RhodesJohn C Crabbe
Dec 13, 2005·Alcoholism, Clinical and Experimental Research·Yuri A BlednovJohn C Crabbe
Mar 17, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Melisa J WallaceRobert O Messing
Jan 20, 2007·Genes, Brain, and Behavior·J S RhodesJ C Crabbe
Mar 25, 2008·Alcohol·Naomi YoneyamaDeborah A Finn
Mar 24, 2009·Alcoholism, Clinical and Experimental Research·Sebastien CarnicellaDorit Ron
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jérémie NeastaDorit Ron

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Citations

Feb 3, 2016·Frontiers in Behavioral Neuroscience·Jason A BubierElissa J Chesler
Aug 3, 2013·Alcoholism, Clinical and Experimental Research·Anna M LeeRobert O Messing
Mar 26, 2016·Alcoholism, Clinical and Experimental Research·Megan E TippsKari J Buck
Dec 25, 2019·Alcoholism, Clinical and Experimental Research·Paula A ZamudioJohn J Woodward
Aug 23, 2020·Brain Sciences·Lauren C Smith, Adam Kimbrough
Mar 2, 2013·Addiction Biology·Vez Repunte-CanonigoPietro Paolo Sanna
Nov 30, 2018·PloS One·Victor JimenezFernando P Monroy
Oct 28, 2020·Brain Sciences·Michael C Salling, Neil L Harrison
Jan 7, 2021·Journal of Neurophysiology·Andrew D ChappMark J Thomas

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Methods Mentioned

BETA
one hybrid
three hybrid
transgenic

Software Mentioned

GraphPad
Prism

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