Responses to microinjections of endomorphin and nociceptin into the medullary cardiovascular areas

Clinical and Experimental Pharmacology & Physiology
H N Sapru, V C Chitravanshi

Abstract

1. Cardiovascular effects of microinjections of nociceptin and endomorphin-2 into the following medullary areas were studied in urethane-anaesthetized rats: chemoreceptor projection site (CPS), intermediate portion of the nucleus tractus solitarius (I-NTS), caudal ventrolateral medullary depressor area (CVLM) and rostral ventrolateral medullary pressor area (RVLM). 2. Microinjections of nociceptin or endomorphin-2 (0.6 mmol/L each) into the CPS and RVLM elicited depressor and bradycardic responses, whereas similar injections into the I-NTS and CVLM elicited pressor and tachycardic responses. 3. The mechanism of cardiovascular responses to microinjections of these opioid peptides into different medullary areas involved in cardiovascular function can be postulated as follows: the direct effect of nociceptin and endomorphin-2 on neurons is usually inhibitory. Because the activation of CPS and RVLM by microinjections of L-glutamate results in pressor and tachycardic responses, inhibition of these areas by nociceptin and endomorphin-2 elicits depressor and bradycardic responses. Similarly, activation of neurons in the I-NTS and CVLM by microinjections of L-glutamate elicits depressor and bradycardic responses. Therefore, inhibition ...Continue Reading

References

Dec 1, 1988·Journal of the Autonomic Nervous System·R W Urbanski, H N Sapru
Nov 1, 1996·British Journal of Pharmacology·B NicolA T McKnight
Oct 30, 1999·Naunyn-Schmiedeberg's Archives of Pharmacology·K VaraniD Regoli
Apr 27, 2000·Journal of Chemical Neuroanatomy·T L Pierce, M W Wessendorf
Apr 12, 2001·The Journal of Peptide Research : Official Journal of the American Peptide Society·R GuerriniS Salvadori

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Citations

Aug 16, 2008·Pflügers Archiv : European journal of physiology·Armenak BantikyanChi-Sang Poon
Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Jun 6, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard D WainfordDaniel R Kapusta
Nov 9, 2007·Peptides·Weihong Pan, Abba J Kastin
Jul 8, 2005·Brain Research·Vineet C Chitravanshi, Hreday N Sapru
Sep 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ken KasamatsuHreday N Sapru
Dec 24, 2004·Journal of Neurophysiology·Nicholas R Glatzer, Bret N Smith
Jan 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vineet C Chitravanshi, Hreday N Sapru
Feb 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ken Kasamatsu, Hreday N Sapru
Jul 7, 2007·Journal of Neurophysiology·Nicholas R GlatzerBret N Smith
May 30, 2019·Brazilian Oral Research·Fernanda Alvarez de GodoiRoberta Tarkany Basting
Feb 21, 2006·Journal of Paediatrics and Child Health·Mark G GussyNicola M Kilpatrick

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