Responses to pulsatile flow in piglet isolated cerebral arteries

Pediatric Research
L A ShimodaJ A Madden

Abstract

Because cerebrovascular hemorrhage in newborns is often associated with fluctuations in cerebral blood flow, this study was designed to investigate the effects of pulsatile flow in isolated cerebral arteries from neonatal piglets. Arteries mounted on cannulas were bathed in and perfused with a physiologic saline solution. An electronic system produced pulsations, the amplitude and frequency of which were independently controlled. At constant mean transmural pressure (20 mm Hg), increasing flow in steps from 0 to 1.6 mL/min under steady flow conditions caused a biphasic response, constriction at low flow, and dilation at high flow. Under pulsatile flow conditions (pulse amplitude 16-24 mm Hg; 2 Hz), the arteries dilated upon flow initiation and continued to dilate as mean flow increased. Dilation to pulsatile flow did not depend on the level of mean flow because switching from steady to pulsatile flow at each flow step also caused dilation. Arteries dilated further upon increasing either pulse amplitude (12-28 mm Hg; 2 Hz) or frequency (16-24 mm Hg; 4 Hz). Inhibiting nitric oxide synthesis with Nomega-nitro-L-arginine or perfusing with glutaraldehyde to decrease endothelial cell deformability significantly reduced dilations to p...Continue Reading

References

Mar 1, 1978·The Annals of Thoracic Surgery·C Mavroudis
Jan 1, 1979·The Journal of Pediatrics·H C LouB Friis-Hansen
Jan 1, 1991·Acta paediatrica Scandinavica·F Cowan, A Whitelaw
Sep 1, 1991·The American Journal of Physiology·J H SweiryG E Mann
May 1, 1986·The Annals of Thoracic Surgery·T LundarH Nornes
May 1, 1986·Biulleten' eksperimental'noĭ biologii i meditsiny·A M Mel'kumiantsV M Khaiutin
Aug 1, 1985·The Annals of Thoracic Surgery·T LundarH Nornes
Apr 9, 1981·The New England Journal of Medicine·J J Volpe
Dec 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T J GregoryN Sedransk
Feb 17, 1980·Brain Research·M J HernándezG S Bowman
Apr 1, 1996·Pediatric Research·L A ShimodaJ A Madden

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Citations

Feb 8, 2007·Pflügers Archiv : European journal of physiology·Hans Oberleithner
Oct 6, 2001·Critical Care Medicine·J A AdamsM A Sackner
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·M IngyinnM Viswanathan
Nov 23, 2006·Critical Care Medicine·Jose A Adams
Feb 9, 2012·The Journal of Physiology·Ki Jung Kim, Jessica A Filosa
May 26, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Peter TothAkos Koller
Mar 23, 2010·Biochimica Et Biophysica Acta·Johannes FelsKristina Kusche-Vihrog
Oct 27, 2004·Journal of Applied Physiology·Jose A AdamsMarvin A Sackner
Aug 23, 2005·Biology of the Neonate·J Martínez-OrgadoM P Viveros
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R M BryanT D Johnson

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