Responses to ragweed pollen in a pollen challenge chamber versus seasonal exposure identify allergic rhinoconjunctivitis endotypes

The Journal of Allergy and Clinical Immunology
Robert L JacobsSunil K Ahuja

Abstract

The level of concordance between allergic symptoms induced on exposure to pollen in a pollen challenge chamber (PCC) versus the natural season is unknown. We sought to test the hypothesis that the symptom levels of allergic rhinoconjunctivitis elicited after out-of-season exposure to short ragweed in a PCC and during the natural season for giant ragweed pollen are highly correlated. Thirty-one ragweed-sensitive participants recorded symptoms for 15 days during the natural giant ragweed season in San Antonio, Texas. Twenty-six of these participants were challenged to short ragweed pollen in a PCC for 3 hours per day for up to 4 days. In the PCC participants were dichotomized into those in whom low versus high levels of symptoms developed slowly or rapidly (ie, slow/low vs rapid/high). Each successive exposure visit associated with a progressive increase in symptom levels that approximated those experienced during the natural season. Hierarchic clustering identified 3 endotypes: endotypes I and II reflected concordantly low (n= 7) versus high (n = 14) total symptom scores (TSSs) in both the natural season and the PCC, respectively. Accordingly, the correlation between the TSSs recorded in the natural season and in the PCC for the...Continue Reading

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Citations

Mar 13, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Melina MakatsoriMoises A Calderon
Oct 16, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Anne K EllisLisa M Steacy
Oct 29, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Lars H ChristensenKaare Lund
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Jul 2, 2015·Current Allergy and Asthma Reports·Michelle L NorthAnne K Ellis
Feb 1, 2015·The Journal of Allergy and Clinical Immunology·Hendrik NolteFriedrich Horak
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Robert L JacobsSunil K Ahuja
Dec 18, 2013·The Journal of Allergy and Clinical Immunology·Robert L JacobsSunil K Ahuja
Dec 22, 2014·The Journal of Allergy and Clinical Immunology·Karen Rösner-FrieseOliver Pfaar
Mar 7, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Anne K Ellis, Michelle L North
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