PMID: 9184789May 1, 1997Paper

Responses to welding fumes: lung injury, inflammation, and the release of tumor necrosis factor-alpha and interleukin-1 beta

Experimental Lung Research
James M AntoniniJ D Brain

Abstract

Possible mechanisms were examined whereby welding fumes may elicit injury and inflammation in the lungs. The effects of different welding fumes on lung macrophages and on the in vivo production of two inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1 beta), were assessed. Fume was collected during flux-covered manual metal are welding using a stainless steel consumable electrode (MMA-SS) and gas metal are welding using a mild steel electrode (GMA-MS). For the in vitro study, bronchoalveolar lavage was performed on untreated rats to recover lung macrophages, and the effects of the welding fumes on macrophage viability and respiratory burst were examined. In vivo, additional rats were intratracheally instilled with the welding fumes at a dose of 1 mg/100 g body weight. These rats were lavaged 1, 14, and 35 days postinstillation, and indicators of lung damage (cellular differential, albumin. TNF-alpha and IL-1 beta release, and lactate dehydrogenase and beta-n-acetyl glucosaminidase activities) were measured. In vitro, the MMA-SS fume was more cytotoxic to the macrophages and induced a greater release of reactive oxygen species as measured by the respiratory burst compared to the GMA-MS ...Continue Reading

References

Dec 1, 1976·The Annals of Occupational Hygiene·K R AkselssonJ W Winchester
May 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·D M StavertB E Lehnert
Nov 1, 1991·American Journal of Respiratory Cell and Molecular Biology·P GossetA B Tonnel
Nov 1, 1991·Toxicology and Applied Pharmacology·K E DriscollJ Higgins
May 1, 1991·The American Review of Respiratory Disease·S J Sferlazza, W S Beckett
Feb 1, 1990·Toxicology and Applied Pharmacology·R C LindenschmidtK A Belfiore
Apr 1, 1990·American Journal of Respiratory Cell and Molecular Biology·K E DriscollG Ridder
Dec 1, 1989·American Journal of Respiratory Cell and Molecular Biology·S L KunkelD G Remick
Jan 1, 1988·British Journal of Industrial Medicine·C MagnaniD Coggon
Jan 1, 1988·The Annals of Occupational Hygiene·R N HooftmanP Roza
Jan 1, 1986·Journal of Toxicology and Environmental Health·J T PasanenJ O Järvisalo
Sep 1, 1983·Environmental Health Perspectives·R M Stern, G H Pigott
Dec 1, 1994·Environmental Health Perspectives·J L Farber
Dec 1, 1994·Environmental Health Perspectives·B Halliwell, C E Cross
Feb 24, 1995·The Science of the Total Environment·T V O'Donnell
Feb 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R F HendersonE B Barr
May 1, 1993·Journal of Applied Toxicology : JAT·R von Burg, D Liu

❮ Previous
Next ❯

Citations

Nov 12, 2005·Molecular and Cellular Biochemistry·James M AntoniniMichael D Taylor
Dec 19, 2003·Journal of Toxicology and Environmental Health. Part a·James M AntoniniJenny R Roberts
Jul 27, 2007·Journal of Toxicology and Environmental Health. Part a·Kyung Taek RimIl Je Yu
Mar 15, 2006·Journal of Occupational and Environmental Hygiene·James M AntoniniDavid G Frazer
May 17, 2011·Particle and Fibre Toxicology·Jae Hyuck SungIl Je Yu
Feb 28, 2008·Journal of Occupational Medicine and Toxicology·Sigve W ChristensenOyvind Omland
Oct 30, 2008·Journal of Immunotoxicology·Stacey E AndersonAlbert E Munson
Feb 25, 2009·Inhalation Toxicology·Mi Jin YangChang Woo Song
Feb 15, 2003·Critical Reviews in Toxicology·James M Antonini
Mar 20, 2003·American Journal of Industrial Medicine·James M AntoniniDavid A Whaley
Oct 12, 2004·Toxicology Letters·Il Je YuKwang Jong Kim
May 20, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lauren F ChunJeffrey E Gotts
May 22, 2013·International Journal of Occupational Medicine and Environmental Health·Merja JärveläTimo Hannu
Jul 8, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Li LiXiaodong Tang
Apr 12, 2020·International Journal of Environmental Research and Public Health·Maria Grazia RiccelliMassimo Corradi
May 29, 2021·Journal of Occupational and Environmental Medicine·Peter BrandRahul Sharma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Toxicology and Environmental Health. Part a
James M AntoniniJ D Brain
Toxicological Sciences : an Official Journal of the Society of Toxicology
I J YuH K Chung
American Journal of Industrial Medicine
U BuerkeH-J Woitowitz
American Industrial Hygiene Association Journal
W K Morgan
International Archives of Occupational and Environmental Health
F Akbar-Khanzadeh
© 2021 Meta ULC. All rights reserved