Responsible, practical genomic data sharing that accelerates research.

Nature Reviews. Genetics
James Brian ByrdCasey S Greene

Abstract

Data sharing anchors reproducible science, but expectations and best practices are often nebulous. Communities of funders, researchers and publishers continue to grapple with what should be required or encouraged. To illuminate the rationales for sharing data, the technical challenges and the social and cultural challenges, we consider the stakeholders in the scientific enterprise. In biomedical research, participants are key among those stakeholders. Ethical sharing requires considering both the value of research efforts and the privacy costs for participants. We discuss current best practices for various types of genomic data, as well as opportunities to promote ethical data sharing that accelerates science by aligning incentives.

Associated Datasets

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Citations

Sep 16, 2020·Nature Reviews. Genetics
Nov 25, 2020·Trends in Cancer·Ariel A Hippen, Casey S Greene
Apr 13, 2021·FEBS Letters·Samantha L WilsonMichael M Hoffman
Apr 17, 2021·Genome Biology·Anushka RajeshSerghei Mangul
Apr 24, 2021·Clinical Linguistics & Phonetics·Alice LeeMartin J Ball
Aug 20, 2021·Cell Systems·Matthias MannMaximilian T Strauss
Sep 1, 2021·Nature Methods·Benjamin J HeilStephanie C Hicks
Oct 8, 2021·PLoS Biology·Gregory P WayElana J Fertig

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Datasets Mentioned

BETA
45

Methods Mentioned

BETA
genotyping
methylation profiling
immunoprecipitation
RNA-seq

Software Mentioned

Synapse
TCGA
Zenodo
All
DMPTool
ArrayExpress
Genome Aggregation Database ( gnomAD )
Figshare

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