Responsive Hydrogel Nanoparticles for Pulmonary Delivery

Journal of Drug Delivery Science and Technology
Nathanael A StockeJ Zach Hilt

Abstract

Nanoparticles represent one of the most widely studied classes of advanced drug delivery platforms in recent years due to a wide range of unique properties and capabilities that can be utilized to improve upon traditional drug administration. Conversely, hydrogel nanoparticles (HNPs) - also called nanogels - represent a unique class of materials that combine the intrinsic advantages of nanotechnology with the inherent capabilities of hydrogels. Responsive hydrogels pose a particularly interesting class of materials that can sense and respond to external stimuli and previous reports of inhalable hydrogel particles have highlighted their potential in pulmonary delivery. Here, we synthesized two different pH-responsive HNPs, designated HNP120 and HNP270, by incorporating functional monomers with a common crosslinker and characterized their physicochemical properties. One of the HNP systems was selected for incorporation into a composite dry powder by spray drying, and the aerodynamic performance of the resulting powder was evaluated. The HNP120s displayed a hydrodynamic diameter of approximately 120 nm in their fully swollen state and a minimal diameter of around 80 nm while the HNP270s were approximately 270 nm and 115 nm, respec...Continue Reading

References

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Citations

Jun 15, 2018·Pharmaceutics·Ian P Harrison, Fabrizio Spada
Sep 16, 2017·Biophysics Reviews·Adriana Lopes da SilvaMarcelo Marcos Morales
Nov 24, 2021·Advanced Healthcare Materials·Angela M GutierrezJ Zach Hilt

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