Responsive organogels formed by supramolecular self assembly of PEG-block-allyl-functionalized racemic polypeptides into β-sheet-driven polymeric ribbons.

Soft Matter
Jiong ZouKaren L Wooley

Abstract

A chemically reactive hybrid diblock polypeptide gelator poly(ethylene glycol)-block-poly(dl-allylglycine) (PEG-b-PDLAG) is an exceptional material, due to the characteristics of thermo-reversible organogel formation driven by the combination of a hydrophilic polymer chain linked to a racemic oligomeric homopeptide segment in a range of organic solvents. One-dimensional stacking of the block copolymers is demonstrated by ATR-FTIR spectroscopy, wide-angle X-ray scattering to be driven by the supramolecular assembly of β-sheets in peptide blocks to afford well-defined fiber-like structures, resulting in gelation. These supramolecular interactions are sufficiently strong to achieve ultra low critical gelation concentrations (ca. 0.1 wt%) in N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and methanol. The critical gel transition temperature was directly proportional to the polymer concentration, so that at low concentrations, thermoreversibility of gelation was observed. Dynamic mechanical analysis studies were employed to determine the organogel mechanical properties, having storage moduli of ca. 15.1 kPa at room temperature.

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Citations

Jun 26, 2014·Chemistry : a European Journal·Jiong ZouKaren L Wooley
Jun 17, 2016·Chemical Communications : Chem Comm·Xun HeKaren L Wooley
Dec 8, 2016·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Chao AnWen-Jiao Xue
Nov 8, 2017·Macromolecular Rapid Communications·Niels Ten BrummelhuisHans G Börner
Sep 29, 2015·Soft Matter·Mthulisi KhuphePaul D Thornton
Dec 9, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xun HeKaren L Wooley
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Zuofa YanJialu Xiao
Jul 17, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Rita Das Mahapatra, Joykrishna Dey
May 29, 2016·Biomacromolecules·Charlotte D VacogneHelmut Schlaad

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