Responsiveness of impairments and disabilities in Parkinson's disease

Parkinsonism & Related Disorders
M VisserJacobus J van Hilten

Abstract

The objective of this study is to evaluate the responsiveness of items of the Activities of Daily Living (ADL) and Motor section of the Unified Parkinson's Disease Rating Scale (UPDRS) in patients with Parkinson's Disease (PD). A standardized Response Mean (SRM) per item was calculated using data of four trials (n=376) that randomised patients with early PD to dopamine agonist (DA) monotherapy or placebo. In the ADL section, the SRMs ranged from -0.04 (no effect) to -0.50 (moderate effect). Hand functions were the most responsive ADL items with 'handwriting' showing the largest response. Self-assessed symptoms were the least responsive. In the Motor section, SRMs ranged from -0.09 to -0.60 with bradykinesia items showing the largest response, especially the item 'finger taps'. The tremor items showed the smallest response, however, rest tremor arms was much more responsive than rest tremor of the head and legs or postural tremor. SRMs in the placebo group ranged from 0.08 to -0.21 in the ADL section and from 0.03 to -0.35 in the Motor section. ADL and motor items have comparable and mostly small effect sizes. The most responsive items are in the ADL section hand functions and in the Motor section bradykinesia items. A more resp...Continue Reading

References

May 1, 1985·Journal of the Neurological Sciences·J P Lakke
Jan 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·P Martínez-MartínF Bermejo
Jan 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·J J van HiltenR A Roos
Jan 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·M RichardsR Mayeux
Aug 1, 1995·Clinical Neuropharmacology·J P HubbleA Elvin
Sep 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·B R BloemR A Roos
Jan 1, 1997·Annals of Neurology·F J VingerhoetsB J Snow
May 1, 1997·Journal of Clinical Epidemiology·A F de BruinH Philipsen
Aug 1, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·G T Stebbins, C G Goetz
Apr 6, 1999·Archives of Neurology·E D LouisK Marder
Feb 19, 2000·Neurology·C G GoetzG T Stebbins
Jun 27, 2001·Neurology·N GiladiUNKNOWN Parkinson Study Group
Mar 23, 2002·Neurology·Rodger J Elble
Mar 29, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Parkinson Study Group
May 23, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·B H WoodR W Walker
Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Andrew SiderowfUNKNOWN Parkinson Study Group
Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Claudia RamakerBob Johannes Van Hilten
Sep 23, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Pablo Martínez-MartínIvana Zamarbide

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Citations

Mar 10, 2010·Journal of Neurologic Physical Therapy : JNPT·Sujata D PradhanYoky Matsuoka
Jun 19, 2009·Journal of Neurophysiology·Xin FengChristy L Ludlow
Jul 23, 2015·Journal of the Neurological Sciences·Kristopher KimmellElliott D Ross
Mar 21, 2007·Parkinsonism & Related Disorders·A HaffendenO Suchowersky
Nov 4, 2015·Neuropsychologia·Jing ChenLi Li
Apr 9, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Stephanie M van RoodenJacobus J van Hilten
Jul 24, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Pablo Martínez-MartinHudson Mourão Mesquita
Jul 24, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Charlotte A HaaxmaMartin W I M Horstink
Aug 6, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Avner ShaharJack M Guralnik
Nov 5, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A F GiganteG Defazio
Oct 11, 2014·Archives of Physical Medicine and Rehabilitation·Elizabeth L ProudMeg E Morris
Apr 25, 2017·International Journal of Occupational Safety and Ergonomics : JOSE·Kyeong-Hee ChoiYong-Ku Kong

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