Responsiveness of intrinsic subtypes to adjuvant anthracycline substitution in the NCIC.CTG MA.5 randomized trial.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Maggie C U CheangTorsten O Nielsen

Abstract

Recent studies suggest that intrinsic breast cancer subtypes may differ in their responsiveness to specific chemotherapy regimens. We examined this hypothesis on NCIC.CTG MA.5, a clinical trial randomizing premenopausal women with node-positive breast cancer to adjuvant CMF (cyclophosphamide-methotrexate-fluorouracil) versus CEF (cyclophosphamide-epirubicin-fluorouracil) chemotherapy. Intrinsic subtype was determined for 476 tumors using the quantitative reverse transcriptase PCR PAM50 gene expression test. Luminal A, luminal B, HER2-enriched (HER2-E), and basal-like subtypes were correlated with relapse-free survival (RFS) and overall survival (OS), estimated using Kaplan-Meier plots and log-rank testing. Multivariable Cox regression analyses determined significance of interaction between treatment and intrinsic subtypes. Intrinsic subtypes were associated with RFS (P = 0.0005) and OS (P < 0.0001) on the combined cohort. The HER2-E showed the greatest benefit from CEF versus CMF, with absolute 5-year RFS and OS differences exceeding 20%, whereas there was a less than 2% difference for non-HER2-E tumors (interaction test P = 0.03 for RFS and 0.03 for OS). Within clinically defined Her2(+) tumors, 79% (72 of 91) were classified ...Continue Reading

References

Jul 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mark N LevineUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Aug 18, 2005·Journal of the National Cancer Institute·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roman RouzierLajos Pusztai
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John J DoyleDawn L Hershman
May 19, 2006·The New England Journal of Medicine·Kathleen I PritchardUNKNOWN National Cancer Institute of Canada Clinical Trials Group
May 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Soonmyung PaikNorman Wolmark
Apr 18, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lisa A CareyCharles M Perou
Feb 6, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cornelia LiedtkeLajos Pusztai
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joel S ParkerPhilip S Bernard
Apr 30, 2009·Journal of the National Cancer Institute·F P O'MalleyK I Pritchard
May 14, 2009·Journal of the National Cancer Institute·Maggie C U CheangTorsten O Nielsen
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K David VoducHagen Kennecke
Sep 15, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenMatthew J Ellis
Dec 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael F PressDennis J Slamon
Mar 3, 2012·The Lancet Oncology·Brittany L LeePaul E Goss

❮ Previous
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Citations

Jul 12, 2013·Drugs·Valentina GuarneriPierfranco Conte
Oct 1, 2013·The Breast : Official Journal of the European Society of Mastology·Harold J Burstein
May 25, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer R WonTorsten O Nielsen
Nov 21, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S GuiuJ S Reis-Filho
Aug 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jan 16, 2013·Cancer Discovery·Matthew J Ellis, Charles M Perou
Jan 2, 2014·Breast Cancer Research and Treatment·Andrea RoccaDino Amadori
Aug 21, 2014·Journal of the National Cancer Institute·Aleix PratJosé Baselga
Aug 21, 2014·Journal of the National Cancer Institute·Matthew James Ellis
Feb 13, 2016·Health Technology Assessment : HTA·Robert C SteinUNKNOWN OPTIMA Trial Management Group
Apr 25, 2014·Expert Opinion on Drug Discovery·Cristiano Ferrario, Gerald Batist
Aug 7, 2013·Hematology/oncology Clinics of North America·Elisabetta MunzoneMarco Colleoni
Jan 16, 2016·Histopathology·Zuzana Kos, David J Dabbs
Sep 1, 2015·The Breast : Official Journal of the European Society of Mastology·Christopher D HartAngelo Di Leo
Aug 10, 2015·The Breast : Official Journal of the European Society of Mastology·Daniel G Stover, Eric P Winer
Aug 9, 2015·The Breast : Official Journal of the European Society of Mastology·Aleix PratMontserrat Muñoz
Mar 14, 2013·International Journal of Cancer. Journal International Du Cancer·Alaa M AliPaul D Pharoah
May 31, 2015·Clinical Breast Cancer·Eunpi ChoVijayakrishna K Gadi
Aug 25, 2015·BMC Medical Genomics·Brett WalldenJoel S Parker
Sep 5, 2015·Journal of Cancer Epidemiology·Carol A Parise, Vincent Caggiano
Oct 22, 2013·Cancer Treatment Reviews·Nadia HarbeckSophie Doisneau-Sixou
Apr 19, 2015·Breast Cancer Research : BCR·Paolo NuciforoMaurizio Scaltriti
Sep 19, 2016·Seminars in Cancer Biology·Timur R SamatovUdo Schumacher
Dec 6, 2016·Expert Review of Molecular Diagnostics·Hin-Fung TsangSze-Chuen Cesar Wong
Jan 7, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katherine L Pogue-GeileSoonmyung Paik
May 10, 2017·The Breast Journal·Henry G KaplanMary K Atwood
Jan 17, 2013·Translational Oncology·Enrique Espinosa ArranzPilar Zamora
Apr 6, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R YerushalmiK A Gelmon
Jul 1, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bent EjlertsenHenning T Mouridsen
Jan 30, 2018·Frontiers in Oncology·Robin L AndersonKara L Britt
May 1, 2018·International Journal of Cancer. Journal International Du Cancer·Jie LiChaohan Xu
Oct 17, 2015·Journal of breast cancer·Hyun-Ah KimUNKNOWN Korea Breast Cancer Society
Nov 10, 2018·International Journal of Cancer. Journal International Du Cancer·Karama AslehTorsten O Nielsen
Apr 25, 2015·The Oncologist·Maggie C U CheangLisa A Carey

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