PMID: 940593Feb 25, 1976Paper

Responsiveness of isolated canine cerebral and peripheral arteries to ergotamine

Naunyn-Schmiedeberg's Archives of Pharmacology
E MULLER-Schweinitzer

Abstract

Changes in tension of spiral strips from dog saphenous, external carotid and basilar arteries were monitored isometrically. Serotonin (5-HT) contracted the 3 arterial preparations in about the same concentration range. Compared with noradrenaline (NA) (100%) the efficacy of 5-HT was about 60% on saphenous, 150% on external carotid and about 500% on basilar arteries. Ergotamine (E) stimulated the 3 vascular preparations in concentrations about 100 times lower than 5-HT. Compared with NA the efficacy of E was about 20% on saphenous, 50% on external carotid and 200% on basilar arteries. Compared with 5-HT (100%) however, E had similar constrictor activities in the 3 arteries. It seemed likely therefore that 5-HT receptors are involved in the vasoconstrictor activity of E. Evidence for this was obtained in experiments in which cyproheptadine (Cy), a 5-HT antagonist, was used. For antagonism of E concentrations of Cy about 6 times higher than those required to inhibit 5-HT were necessary, whereas for antagonism of NA about 500 times higher Cy concentrations were necessary. The results suggest that on canine arterial vascular smooth muscle the constrictor activity of E is mediated mainly through serotoninergic receptor sites.

References

Jul 1, 1974·British Journal of Pharmacology·E Müller-Schweinitzer, E Stürmer
Dec 1, 1973·The American Journal of Physiology·R F Lowe, D D Gilboe
Aug 1, 1972·The Journal of Pharmacy and Pharmacology·C von Essen
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Sep 1, 1963·Neurology·P KARLSBERGJ E ADAMS

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Citations

Feb 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·E Müller-Schweinitzer
Oct 12, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·E Müller-Schweinitzer
Feb 19, 1979·European Journal of Clinical Pharmacology·V Ala-HurulaE Hokkanen
Nov 1, 1979·European Journal of Clinical Pharmacology·V Ala-HurulaE Hokkanen
Sep 1, 1977·Agents and Actions·E Müller-Schweinitzer, H Weidmann
Jun 13, 1980·European Journal of Pharmacology·M Sakanashi, K I Yonemura
Jan 1, 1983·General Pharmacology·E Mikkelsen, O L Pedersen
Jan 1, 1983·General Pharmacology·E Müller-Schweinitzer
Apr 1, 1978·Postgraduate Medical Journal·E S Johnson
Aug 1, 1980·The Journal of Clinical Investigation·P D Henry, M Yokoyama
Dec 1, 1981·Cephalalgia : an International Journal of Headache·J R OstergaardB Voldby
Apr 1, 1984·Acta Pharmacologica Et Toxicologica·E MikkelsenO L Pedersen
Nov 4, 1978·The Medical Journal of Australia·B Berde
Aug 1, 1984·Biochemical Pharmacology·S J Peroutka

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