PMID: 940593Feb 25, 1976Paper

Responsiveness of isolated canine cerebral and peripheral arteries to ergotamine

Naunyn-Schmiedeberg's Archives of Pharmacology
E MULLER-Schweinitzer


Changes in tension of spiral strips from dog saphenous, external carotid and basilar arteries were monitored isometrically. Serotonin (5-HT) contracted the 3 arterial preparations in about the same concentration range. Compared with noradrenaline (NA) (100%) the efficacy of 5-HT was about 60% on saphenous, 150% on external carotid and about 500% on basilar arteries. Ergotamine (E) stimulated the 3 vascular preparations in concentrations about 100 times lower than 5-HT. Compared with NA the efficacy of E was about 20% on saphenous, 50% on external carotid and 200% on basilar arteries. Compared with 5-HT (100%) however, E had similar constrictor activities in the 3 arteries. It seemed likely therefore that 5-HT receptors are involved in the vasoconstrictor activity of E. Evidence for this was obtained in experiments in which cyproheptadine (Cy), a 5-HT antagonist, was used. For antagonism of E concentrations of Cy about 6 times higher than those required to inhibit 5-HT were necessary, whereas for antagonism of NA about 500 times higher Cy concentrations were necessary. The results suggest that on canine arterial vascular smooth muscle the constrictor activity of E is mediated mainly through serotoninergic receptor sites.


Jul 1, 1974·British Journal of Pharmacology·E Müller-Schweinitzer, E Stürmer
Dec 1, 1973·The American Journal of Physiology·R F Lowe, D D Gilboe
Aug 1, 1972·The Journal of Pharmacy and Pharmacology·C von Essen
Feb 1, 1974·European Journal of Pharmacology·B B Vargaftig, J Lefort
Jan 1, 1974·Acta Neurologica Scandinavica·B Ekström-JodalB E Roos
May 1, 1967·Archives of Neurology·M AnthonyJ W Lance
Jun 1, 1957·British Journal of Pharmacology and Chemotherapy·A CARPI, M VIRNO
Sep 1, 1963·Neurology·P KARLSBERGJ E ADAMS

❮ Previous
Next ❯


Feb 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·E Müller-Schweinitzer
Oct 12, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·E Müller-Schweinitzer
Feb 19, 1979·European Journal of Clinical Pharmacology·V Ala-HurulaE Hokkanen
Nov 1, 1979·European Journal of Clinical Pharmacology·V Ala-HurulaE Hokkanen
Sep 1, 1977·Agents and Actions·E Müller-Schweinitzer, H Weidmann
Jun 13, 1980·European Journal of Pharmacology·M Sakanashi, K I Yonemura
Jan 1, 1983·General Pharmacology·E Mikkelsen, O L Pedersen
Jan 1, 1983·General Pharmacology·E Müller-Schweinitzer
Apr 1, 1978·Postgraduate Medical Journal·E S Johnson
Aug 1, 1980·The Journal of Clinical Investigation·P D Henry, M Yokoyama
Dec 1, 1981·Cephalalgia : an International Journal of Headache·J R OstergaardB Voldby
Apr 1, 1984·Acta Pharmacologica Et Toxicologica·E MikkelsenO L Pedersen
Nov 4, 1978·The Medical Journal of Australia·B Berde
Aug 1, 1984·Biochemical Pharmacology·S J Peroutka

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Related Papers

Archives of Neurology
M AnthonyJ W Lance
JAMA : the Journal of the American Medical Association
© 2021 Meta ULC. All rights reserved