Responsiveness of patient-based and external rating scales in multiple sclerosis: head-to-head comparison in three clinical settings

Journal of the Neurological Sciences
S M GoldC Heesen

Abstract

Patient-based rating scales and especially quality of life scales have received increasing attention as secondary outcome measures in multiple sclerosis (MS). Responsiveness to health-related change of quality of life scales is thus an important property when these measures are to be used successfully in clinical trials. We conducted an analysis of 3 cohorts of MS patients to examine responsiveness of the Hamburg Quality of Life Questionnaire for Multiple Sclerosis (HAQUAMS). One cohort consisted of patients from the outpatient clinic whose overall health status deteriorated over the course of one year (n=53), one study investigated two neurorehabilitation programs (n=20 each) and a third study investigated a low-level aerobic fitness training intervention (n=15). The total score of the HAQUAMS and several subscales was found to be responsive in all three settings. In addition, we provide minimally important difference (MID) estimates based on anchor- and distribution-based methods for all scales of the HAQUAMS. The HAQUAMS is responsive to change in observational and intervention studies in MS in adequately powered trials.

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Citations

Mar 28, 2013·Multiple Sclerosis International·Karine BaumstarckPascal Auquier
Feb 13, 2013·Acta Neurologica Scandinavica·N SchäfflerC Heesen
May 27, 2015·Multiple Sclerosis and Related Disorders·Rana KarabudakBassem I Yamout
Jun 25, 2013·Journal of the Neurological Sciences·Y C LearmonthR W Motl
Jul 7, 2012·Neuropharmacology·Graham NiepelCris S Constantinescu
Jul 6, 2011·Multiple Sclerosis : Clinical and Laboratory Research·X MontalbanL Kappos
Jul 12, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V KhuranaJ Medin
Mar 20, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Jana PöttgenStefan M Gold
Mar 19, 2019·Brain and Behavior·Laura Melanie SchaeferChristoph Heesen
Nov 10, 2018·Nature Reviews. Disease Primers·Massimo FilippiMaria A Rocca

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