Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogues

British Journal of Pharmacology
S E BurkeJ B Smith

Abstract

1--Platelet-rich plasma (PRP) from humans, cats, dogs (after addition of 10 microM adrenaline), rabbits and guinea-pigs aggregated in response to sodium arachidonate or 9,11-azo-prostaglandin H2, while PRP obtained from sheep was unresponsive to either agent. 2--The stable thromboxane (Tx) analogues, carbocyclic TxA2 (CTA2) and pinane TxA2 (PTA2) significantly inhibited these aggregatory responses in platelets from humans, dogs and guinea-pigs, while PTA2 but not CTA2 produced significant inhibition in cat platelets. The aggregatory response of PRP from rabbits was not significantly blocked by either analogue. 3--CTA2 and the endoperoxide analogue 9,11-methanoepoxy PGH2 (U-46619) constricted coronary arteries from cats, dogs, rabbits and guinea-pigs, while sheep vessels were unresponsive to either analogue. 4--Vasoconstrictor responses to U-46619 were significantly attenuated by PTA2 in vessels from all species. However, constriction produced by CTA2 was blocked significantly only in vessels from cats, dogs and guinea-pigs. 5--These results demonstrate the species differences which exist in the responsiveness of platelets and coronary arteries to thromboxane and endoperoxide analogues. Furthermore, the results illustrate the im...Continue Reading

References

Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·K C NicolaouA M Lefer
Jun 1, 1979·Experimental and Molecular Pathology·S MorookaT Shimamoto
Apr 1, 1979·Prostaglandins and Medicine·R I LewyL Wiener
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E J CoreyB Samuelsson
Sep 1, 1974·Thrombosis Research·J B SmithJ J Kocsis
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A M LeferK C Nicolaou
May 1, 1981·The Journal of Clinical Investigation·C Ingerman-WojenskiE Macarak
Aug 22, 1980·European Journal of Pharmacology·H H WangK E Eakins

Citations

Oct 1, 1991·Clinical Cardiology·S P KarasM B Gravanis
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M IwaiT Shimazu
Sep 1, 1991·Medicinal Research Reviews·S E Hall
Nov 12, 1986·European Journal of Pharmacology·P V HalushkaM Garvin
Jan 6, 1987·European Journal of Pharmacology·A YanagisawaA M Lefer
Jun 22, 1988·European Journal of Pharmacology·S MiharaT Okabayashi
Aug 2, 1988·European Journal of Pharmacology·G T SwayneD A Owen
Sep 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·M A PackhamR L Kinlough-Rathbone
May 1, 1995·General Pharmacology·R A Armstrong, N H Wilson
Oct 1, 1995·Journal of Lipid Mediators and Cell Signalling·F UshikubiS Narumiya
Feb 1, 1996·Journal of Pharmacological and Toxicological Methods·W A SchumacherS K Durham
Jan 1, 1996·Pharmacology & Therapeutics·R A Armstrong
Apr 13, 2000·Pharmacology & Therapeutics·Dirk J Duncker, Robert J Bache
Mar 15, 2001·European Journal of Medicinal Chemistry·M P CatonM F Ansell
Mar 1, 1992·Journal of the American College of Cardiology·L WrightRobert J Bache
Aug 1, 1991·The Journal of Pharmacy and Pharmacology·S G Hui, C W Ogle
Sep 1, 1995·The Journal of Pharmacy and Pharmacology·K YokotaM Oda
Jan 29, 2011·Journal of Biomedicine & Biotechnology·Gemma VilahurLina Badimon
Nov 1, 1984·The Journal of Clinical Investigation·J R SnapperK L Brigham
Oct 4, 2013·BMC Veterinary Research·Annika WeigandJustus P Beier
May 20, 2014·BioMed Research International·Figueroa-Valverde LauroVelázquez-Sarabia Betty Monica
Aug 12, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·C NapoliL O Lerman
Jan 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·S C Hui, C W Ogle
Apr 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J M YanniM H Foxwell
Aug 15, 1992·Thrombosis Research·Y TakiguchiM Nakashima
Apr 1, 1988·British Journal of Pharmacology·R M Tripathi, R Kaushal
Mar 1, 1985·British Journal of Pharmacology·R A ArmstrongN H Wilson
Oct 15, 1993·Thrombosis Research·G SoslauA Pelleg
Feb 1, 1987·Circulation Research·H H HolzgrefeS Bunting
Jul 1, 1987·Stroke; a Journal of Cerebral Circulation·R L HaberlE F Ellis
Feb 1, 1988·European Journal of Clinical Investigation·K Jaschonek, C P Muller
Jul 26, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Eva H C TangPaul M Vanhoutte
Jul 16, 2008·Physiological Reviews·Dirk J Duncker, Robert J Bache
May 5, 1999·Journal of Cardiovascular Pharmacology·S Lockyer, J Kambayashi
Mar 1, 1987·Basic Research in Cardiology·A Yanagisawa, A M Lefer
Oct 3, 1999·Physiological Reviews·S NarumiyaF Ushikubi

Related Concepts

Metazoa
Blood Platelets
Felis catus
Sinus Node Artery
Canis familiaris
Cavia porcellus
Platelet Aggregation
Prostaglandin Endoperoxides, Synthetic
Chinchilla Rabbits
Dall Sheep

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.