Responsiveness of the adult male rat reproductive tract to 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: Ah receptor and ARNT expression, CYP1A1 induction, and Ah receptor down-regulation

Toxicology and Applied Pharmacology
B L RomanR E Peterson

Abstract

Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) either in adulthood or during late fetal and early postnatal development causes a variety of adverse effects on the male rat reproductive system. It was therefore of interest to identify male rat reproductive organs and cell types within these organs that might be direct targets of TCDD exposure. Because TCDD toxicity could possibly be the result of alterations in gene transcription mediated by the TCDD/aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex, the presence of the AhR and ARNT in the various organs of the adult male reproductive tract was examined using Western blotting. Both proteins were detectable in all organs examined (testis, epididymis, vas deferens, ventral prostate, dorsolateral [combined dorsal and lateral] prostate, and seminal vesicle). Although technical difficulties precluded the immunohistochemical evaluation of AhR distribution in these organs, ARNT was localized in all organs in a variety of cell types, including germ cells, epithelial cells, fibroblasts, smooth muscle cells, and endothelial cells. Subcellular localization varied across organs and across cell types within these organs. In order to determine whether TCDD exposu...Continue Reading

References

Aug 14, 1987·Biochemical and Biophysical Research Communications·A Poland, E Glover
Feb 1, 1988·Biochemical Pharmacology·R W Moore, R E Peterson
Jun 15, 1985·Toxicology and Applied Pharmacology·R W MooreR E Peterson
Jan 13, 1984·Biochemical and Biophysical Research Communications·T A GasiewiczG Rucci
Jan 1, 1982·Toxicology Letters·P SöderkvistJ A Gustafsson
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Nov 3, 1995·The Journal of Biological Chemistry·H I SwansonC A Bradfield
Jan 1, 1995·Canadian Journal of Physiology and Pharmacology·J V GiannoneP A Harper
Oct 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·B D Abbott, M R Probst
Sep 1, 1996·Toxicology and Applied Pharmacology·P M Fernandez-SalgueroF J Gonzalez
Jan 1, 1996·Annual Review of Cell and Developmental Biology·J V Schmidt, C A Bradfield

❮ Previous
Next ❯

Citations

Oct 22, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Steven R Jones, Daniel G Cyr
Feb 28, 2007·The Journal of Reproduction and Development·Amanda Louise TrewinReinhold J Hutz
Apr 7, 2010·Environmental Health Perspectives·Warren G FosterDaniel G Cyr
Nov 3, 2005·Environmental Health Perspectives·Joanna Y WilsonJohn J Stegeman
Jul 19, 2008·International Journal of Andrology·A AdamssonJ Toppari
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·Y Z GuC A Bradfield
Sep 29, 2000·Biochemical Pharmacology·A PugaM Medvedovic
Jun 28, 2007·Toxicology and Applied Pharmacology·Kimberly R BarnettJodi A Flaws
Sep 15, 2004·Mutation Research·Sébastien GarryDaniel Marzin
Jun 29, 2011·Ciência & saúde coletiva·Warren G FosterDaniel G Cyr
Jun 14, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Neelakanteswar AluruMathilakath M Vijayan
Apr 19, 2017·Molecular and Cellular Biology·Sandra Luecke-JohanssonLorenz Poellinger
Jun 12, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·Deborah A Hansen
Feb 11, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·David C VolzSeth W Kullman
Apr 24, 2010·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S DebS M Bandiera
Aug 9, 2019·Ecotoxicology and Environmental Safety·Henriette Meyer-AlertSteffen H Keiter
Jun 5, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·N H FukuzawaC Tohyama
Sep 12, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Asok K DasmahapatraReinhold J Hutz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.