PMID: 8938557Nov 1, 1996Paper

Responsiveness to interferon alpha treatment in patients with chronic hepatitis C coinfected with hepatitis G virus

Journal of Hepatology
T BergU Hopf

Abstract

Patients with chronic hepatitis C are often coinfected with the new identified Flaviviridae-like agent, termed hepatitis G virus (HGV). The aim of the study was to investigate the responsiveness of hepatitis G virus to interferon alpha and to evaluate whether a hepatitis G virus coinfection negatively influences the outcome of treatment in chronic hepatitis C. One hundred and fifteen patients with histologically proven chronic hepatitis C were treated with interferon alpha and investigated for the presence of hepatitis G virus coinfection by nested polymerase chain reaction with primers from the helicase region of hepatitis G virus. All patients received at least 3 MU (range 3-6) interferon alpha thrice weekly for at least 6 months (mean 8, range 6-12). Polymerase chain reaction products of seven pre- and post-treatment hepatitis G virus positive patients were directly sequenced for identification of sequence variability during the follow-up. Eighteen (16%) patients were coinfected with hepatitis G virus. Although nine (50%) of these patients became HGV RNA negative during interferon alpha therapy, only three patients (17%) remained HGV RNA negative at the end of follow-up (mean 24 months). The rate of sustained response of chr...Continue Reading

References

Nov 30, 1989·The New England Journal of Medicine·G L DavisUNKNOWN Hepatitis Interventional Therapy Group
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Jun 1, 1995·Nature Medicine·J N SimonsI K Mushahwar
Jan 18, 1996·The New England Journal of Medicine·T AikawaH Okamoto

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Citations

May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M EnomotoT Monna
Mar 12, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I D DiamantisM Battegay
Jun 16, 2000·Antiviral Research·M Giménez-BarconsJ M Sánchez-Tapias
Sep 24, 1998·Blood Reviews·P Simmonds
May 5, 1998·Transfusion Medicine Reviews·K G Hadlock, S K Foung
Aug 25, 1999·British Journal of Haematology·M CrovattoG Pozzato
Apr 12, 2000·Journal of Viral Hepatitis·S Sherlock
Jan 1, 1997·Vox Sanguinis·P Karayiannis, H C Thomas
Apr 29, 1998·Journal of Pediatric Gastroenterology and Nutrition·J WoelfleM J Lentze
Sep 10, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M BonaciniB Valinluck
Jan 16, 1998·Journal of Gastroenterology and Hepatology·K OkudaY Irie
Mar 20, 1998·Gut·M GuileraJ Rodés
Dec 6, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Giovana Lotici Baggio-Zappia, Celso Francisco Hernandes Granato
Feb 13, 2001·International Journal of Experimental Pathology·M SatharD York
Nov 27, 1999·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·M RobaczewskaB Falkiewicz
Oct 21, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Sukanya RaghuramanR V Shaji
Jun 11, 1999·The American Journal of Gastroenterology·F AkiyoshiK Tanikawa
Apr 14, 1999·The American Journal of Gastroenterology·D J BrandhagenD H Persing
Nov 2, 2018·European Journal of Gastroenterology & Hepatology·Muhammad ShahidRabia Nawaz
Sep 15, 1998·Journal of Gastroenterology and Hepatology·K Okuda
Mar 28, 1998·Scandinavian Journal of Gastroenterology·L M JarvisK Skaug
Feb 17, 2000·The Journal of General Virology·D B SmithP Simmonds
Jun 27, 1997·Biochemical and Biophysical Research Communications·M IkedaN Kato

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