Responsivity of Periaqueductal Gray Connectivity Is Related to Headache Frequency in Episodic Migraine

Frontiers in Neurology
Linda Solstrand DahlbergDavid Borsook

Abstract

Migraineurs show hypersensitivity to sensory stimuli at various stages throughout the migraine cycle. A number of putative processes have been implicated including a dysfunction in the descending pain modulatory system in which the periaqueductal gray (PAG) is considered to play a crucial role. Recurring migraine attacks could progressively perturb this system, lowering the threshold for future attacks, and contribute to disease chronification. Here, we investigated PAG connectivity with other brain regions during a noxious thermal stimulus to determine changes in migraineurs, and associations with migraine frequency. 21 episodic migraine patients and 22 matched controls were included in the study. During functional MRI, a thermode was placed on the subjects' temple delivering noxious and non-noxious heat stimuli. A psychophysiological interaction (PPI) analysis was carried out to examine pain-induced connectivity of the PAG with other brain regions. The PPI analysis showed increased PAG connectivity with the S1 face representation area and the supplementary motor area, an area involved with pain expectancy, in patients with higher frequency of migraine attacks. PAG connectivity with regions involved with the descending pain mo...Continue Reading

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Citations

Nov 7, 2019·Pain·Tibor M SzikszayKerstin Luedtke
Jun 12, 2020·The Journal of Headache and Pain·David B ClemowAndrew M Blumenfeld
Sep 30, 2020·Cephalalgia : an International Journal of Headache·Alessandro S ZagamiGeoffrey A Lambert
Jun 8, 2018·Molecular Neurobiology·Wei-Yi OngDeron R Herr
Feb 23, 2019·Cephalalgia : an International Journal of Headache·Dylan Jozef Hendrik Augustinus HenssenKris Vissers
Nov 11, 2021·Science Translational Medicine·Irene Tracey

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Methods Mentioned

BETA
SMA

Software Mentioned

SPM
FSL
FMRIB
WFU pickatlas
FEAT ( FMRI Expert Analysis Tool )
Linear Image Registration tool ( FLIRT
Linear Motion Correction tool ( MCFLIRT )
Local Analysis of Mixed Effects in FEAT

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