Rest but busy: Aberrant resting-state functional connectivity of triple network model in insomnia

Brain and Behavior
Xiaojuan DongXu Lei

Abstract

One classical hypothesis among many models to explain the etiology and maintenance of insomnia disorder (ID) is hyperarousal. Aberrant functional connectivity among resting-state large-scale brain networks may be the underlying neurological mechanisms of this hypothesis. The aim of current study was to investigate the functional network connectivity (FNC) among large-scale brain networks in patients with insomnia disorder (ID) during resting state. In the present study, the resting-state fMRI was used to evaluate whether patients with ID showed aberrant FNC among dorsal attention network (DAN), frontoparietal control network (FPC), anterior default mode network (aDMN), and posterior default mode network (pDMN) compared with healthy good sleepers (HGSs). The Pearson's correlation analysis was employed to explore whether the abnormal FNC observed in patients with ID was associated with sleep parameters, cognitive and emotional scores, and behavioral performance assessed by questionnaires and tasks. Patients with ID had worse subjective thought control ability measured by Thought Control Ability Questionnaire (TCAQ) and more negative affect than HGSs. Intriguingly, relative to HGSs, patients with ID showed a significant increase i...Continue Reading

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Citations

Aug 20, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea N Goldstein-PiekarskiLeanne M Williams
Dec 23, 2019·Sleep & Breathing = Schlaf & Atmung·Binghu JiangZhanhui Gao
Jun 11, 2018·Current Neurology and Neuroscience Reports·Daniel Ruivo MarquesMiguel Castelo-Branco

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Key Resources (RRID) Mentioned

SCR_007037
SCR_014196
SCR_001953
SCR_015731

Software Mentioned

VBM
Statistical Parametric Mapping SPM8
GIFT

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