Restarting antiplatelet therapy after spontaneous intracerebral hemorrhage: Functional outcomes.

Neurology
Ching-Jen ChenERICH Investigators

Abstract

To compare the functional outcomes and health-related quality of life metrics of restarting vs not restarting antiplatelet therapy (APT) in patients presenting with intracerebral hemorrhage (ICH) in the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) study. Adult patients aged 18 years and older who were on APT before ICH and were alive at hospital discharge were included. Patients were dichotomized based on whether or not APT was restarted after hospital discharge. The primary outcome was a modified Rankin Scale score of 0-2 at 90 days. Secondary outcomes were excellent outcome (modified Rankin Scale score 0-1), mortality, Barthel Index, and health status (EuroQol-5 dimensions [EQ-5D] and EQ-5D visual analog scale scores) at 90 days. The APT and no APT cohorts comprised 127 and 732 patients, respectively. Restarting APT was associated with lower rates of good functional outcome (36.5% vs 40.8%; p = 0.021) and lower Barthel Index scores at 90 days (p = 0.041). The 2 cohorts were then matched in a 1:1 ratio, and the matched cohorts each comprised 107 patients. No difference in primary outcome was observed between restarting vs not restarting APT (35.5% vs 43.9%; p = 0.105). There were also no differences between the...Continue Reading

References

Jul 16, 1992·The New England Journal of Medicine·J E WillardL D Hillis
Dec 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·B FarrellC Warlow
Jul 20, 1989·The New England Journal of Medicine·UNKNOWN Steering Committee of the Physicians' Health Study Research Group
Jan 24, 1980·The New England Journal of Medicine·H J Weiss
Dec 16, 1998·JAMA : the Journal of the American Medical Association·J HeM J Klag
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·J C HemphillS C Johnston
Aug 25, 2001·The New England Journal of Medicine·S YusufUNKNOWN Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
Jul 24, 2002·Neurology·S E VermeerG J E Rinkel
Dec 3, 2005·Stroke; a Journal of Cerebral Circulation·Pertti SaloheimoMatti Hillbom
Jan 26, 2006·Neurology·A ViswanathanE E Smith
Oct 16, 2010·Stroke; a Journal of Cerebral Circulation·Robert W V FlynnAlexander S F Doney
Apr 28, 2011·JAMA : the Journal of the American Medical Association·Tomas JernbergUNKNOWN SWEDEHEART/RIKS-HIA
Sep 7, 2011·Cerebrovascular Diseases·C WeimarUNKNOWN German Stroke Study Collaboration
Dec 22, 2011·Thrombosis and Haemostasis·Boon-Hor ChongChung-Wah Siu
Dec 20, 2012·Advances in Pharmacological Sciences·Sudeep KarveRajesh Balkrishnan
Sep 12, 2013·Stroke; a Journal of Cerebral Circulation·Daniel WooCarl D Langefeld
Sep 8, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Dan-Ni WangNing Wang
Jun 16, 2016·Stroke; a Journal of Cerebral Circulation·Tobias Pilgaard OttosenSøren Paaske Johnsen
Jun 10, 2017·Stroke; a Journal of Cerebral Circulation·Nadeem I KhanEric E Smith

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Citations

Jan 3, 2020·Stroke; a Journal of Cerebral Circulation·Santosh B MurthyUNKNOWN VISTA-ICH Steering Committee Collaborators
Feb 19, 2021·European Stroke Journal·Kristin Tveitan LarsenOle Morten Rønning
Oct 3, 2021·Current Cardiology Reports·Hae Young Baang, Kevin N Sheth
May 28, 2019·Lancet·Wendy C Ziai, Alexander Tsiskaridze

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