Restenosis after carotid endarterectomy: significance of newly acquired risk factors

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
F FluriS T Engelter

Abstract

In patients who had carotid endarterectomy (CEA), the significance of newly acquired cerebrovascular risk factors (CRFs) is unknown. Newly acquired CRFs are defined as CRFs not present prior to CEA (baseline CRFs) but acquired during long-term follow-up. We sought to determine the significance of newly acquired CRFs in CEA patients with regard to progressive ICA disease (> or =50% restenosis; occurrence or progression of contralateral stenosis). In a single-center CEA-registry, 361 CEA patients with annual follow-up visits for 7 years were identified. Hazard ratios (HR) were calculated for (i) any baseline CRF (hypertension, diabetes, hypercholesterolemia, coronary heart disease (CHD), peripheral artery disease (PAD), smoking), (ii) any newly acquired CRF, and (iii) for the use of statins and antihypertensives. No baseline CRF was associated with progressive ICA disease (unadjusted analysis). After adjustment for age and gender, smoking (HR 1.52, 95%CI 1.02-2.26), diabetes (HR 1.64, 95%CI 1.00-2.68), and hypercholesterolemia (HR 1.61, 95%CI 1.03-2.52) were weakly related to progressive ICA disease. Newly acquired hypertension (HR 2.44, 95%CI 1.57-3.79), CHD (HR 2.73, 95%CI 1.81-4.11), diabetes (HR 2.30, 95%CI 1.39-3.80), and PA...Continue Reading

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Citations

May 11, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S T EngelterP A Lyrer
Sep 10, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D J SeiffgeS T Engelter
Oct 21, 2016·Journal of Vascular Surgery·Efthymios D AvgerinosRabih A Chaer
Nov 6, 2010·Journal of Vascular Surgery·Walter DorigoCarlo Pratesi
Aug 2, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H GensickeUNKNOWN Thrombolysis in Stroke Patients (TriSP) collaborators
Apr 21, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Renato CasanaVincenzo Silani
Jul 28, 2013·Stroke; a Journal of Cerebral Circulation·Daniel StrbianTurgut Tatlisumak
Jan 23, 2016·Stroke; a Journal of Cerebral Circulation·Henrik GensickeUNKNOWN Thrombolysis in Stroke Patients (TriSP) Collaborators
Jan 26, 2018·Neurology·Henrik GensickeUNKNOWN Thrombolysis in Stroke Patients (TRISP) Collaborators
Jul 9, 2020·European Stroke Journal·Valerian L AltersbergerUNKNOWN Thrombolysis in Stroke Patients (TRISP) collaborators
Nov 20, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H GensickeUNKNOWN Thrombolysis in Stroke Patients (TRISP) Collaborators
Sep 10, 2011·Neurosurgery·Georgios ZenonosRobert Max Friedlander

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