Resting and exercise arterial dysfunction in anthracycline-treated adult survivors of childhood cancers

Cardio-Oncology
Vivian Wing-Yi LiYiu-Fai Cheung

Abstract

Emerging evidence suggests potential arterial damage with the use of anthracycline-based chemotherapeutic regimens. We determined arterial function at rest and during exercise in anthracycline-treated adult survivors of childhood cancers. Ninety-six adult survivors (54 males) aged 25.0 ± 5.9 years and 60 (30 males) healthy controls were studied. Central systolic blood pressure (cSBP) and radial augmentation index (rAI) was determined by applanation tonometry. Carotid arterial stiffness and intima-media thickness (IMT) were assessed using high-resolution ultrasound. At rest, survivors had significantly greater carotid IMT (p < 0.001) and stiffness index (p < 0.001), and higher cSBP (p = 0.037), rAI (p = 0.004) and rAI adjusted for a heart rate of 75/min (p = 0.009) than controls. At submaximal supine exercise testing, survivors had significantly greater percentage increase in carotid stiffness than controls (p < 0.001). Among survivors, 32 and 53% had respectively carotid IMT and exercise stiffness index exceeding normal (> + 2SD of controls). The slopes of increase in carotid IMT (p < 0.001) and exercise-induced changes in carotid stiffness (p < 0.001) with age were significantly greater in survivors than controls. Multivariate...Continue Reading

References

Jan 1, 1992·Annals of Biomedical Engineering·D A Kass, R P Kelly
May 15, 2001·European Heart Journal·E Braunwald
May 23, 2001·Toxicology Letters·S ZhouK B Wallace
Jan 16, 2002·Circulation·Ian B WilkinsonJohn R Cockcroft
Dec 31, 2002·Journal of Molecular and Cellular Cardiology·Semon WuYing-Shiung Lee
Mar 15, 2005·Endothelium : Journal of Endothelial Cell Research·Varsha KaushalPaulette Mehta
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven E LipshultzSteven D Colan
May 3, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lucille D A DorresteijnWillem Boogerd
Jun 2, 2005·Circulation·Douglas L Mann, Michael R Bristow
Nov 23, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janine NuverJourik A Gietema
Feb 18, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amy Y ChowDavid N Rosenthal
May 19, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kenji TakazawaAkira Yamashina
Jul 3, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Javier GanameLuc Mertens
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Partha MukhopadhyayPál Pacher
Jun 18, 2009·Pediatric Blood & Cancer·Kathleen A MeeskeMarvin D Nelson
Nov 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Narumol ChaosuwannakitW Gregory Hundley
Aug 24, 2010·Progress in Cardiovascular Diseases·Douglas B SawyerChee Chew Lim
Sep 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory T ArmstrongLillian R Meacham
Oct 25, 2013·Pediatric Blood & Cancer·Donald R DengelJulia Steinberger
Apr 22, 2015·Pediatric Blood & Cancer·Julie I KrystalChristine Sethna
Jan 10, 2016·Annals of Internal Medicine·Daniel A MulrooneyMelissa M Hudson
Jan 14, 2017·Circulation·Miranda M FidlerUNKNOWN British Childhood Cancer Survivor Study (BCCSS) Steering Group
Apr 21, 2017·OncoTargets and Therapy·Ioana MozosRodica Mihaescu

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Medical Imaging and Radiation Oncology
Maryna Krawczuk-RybakElzbieta Goscik
Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Shih-Te TuSuh-Hang Hank Juo
© 2021 Meta ULC. All rights reserved