Jun 4, 1976

Resting and stimulated values of model parameters governing transmitter release at a synapse in Aplysia californica

Brain Research
P B WoodsonS H Barondes

Abstract

Transmitter release (R) at a synpase in Aplysia californica can be analyzed in terms of a model with the following parameters: A, the available pool of transmitter; F, the fraction of available pool released by a presynaptic action potential; M, the rate of transmitter mobilization into the available pool; D, the rate constant of demobilization of transmitter from the available pool. In the present paper we show that: (1) beginning with an analysis of the recovery from depression of the second of a pair of disolated EPSPs separated by a series of intervals of about 10-60 sec, and assuming that the recovery is due to refilling of a depleted A, it is possible to estimate resting equilibrium values of these parameters; (2) changes in these parameters when a new equilbrium state is reached after prolonged stimulation (e.g., 300 stimuli at 1/sec) can then be quantitatively determined; (3) the increased rate of transmitter release observed during and after repetitive stimulation is the consequence of increases in F and M with changes in A passively following; and (4) there are significant correlations among certain resting parameters and between the values of certain resting parameters and these parameters upon stimulation. Preparati...Continue Reading

Mentioned in this Paper

Resting Potentials
Action Potentials
Mollusca
Synaptic Transmission
Aplysia californica
Synapses
Ganglia
Neurohormones
Synaptic Membranes
Interphase Cell

About this Paper

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