Resting heart rate, heart rate variability and functional decline in old age

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Giulia OgliariBehnam Sabayan

Abstract

Heart rate and heart rate variability, markers of cardiac autonomic function, have been linked with cardiovascular disease. We investigated whether heart rate and heart rate variability are associated with functional status in older adults, independent of cardiovascular disease. We obtained data from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). A total of 5042 participants were included in the present study, and mean follow-up was 3.2 years. Heart rate and heart rate variability were derived from baseline 10-second electrocardiograms. Heart rate variability was defined as the standard deviation of normal-to-normal RR intervals (SDNN). Functional status in basic (ADL) and instrumental (IADL) activities of daily living was measured using Barthel and Lawton scales, at baseline and during follow-up. The mean age of the study population was 75.3 years. At baseline, higher heart rate was associated with worse ADL and IADL, and lower SDNN was related to worse IADL (all p values < 0.05). Participants in the highest tertile of heart rate (range 71-117 beats/min) had a 1.79-fold (95% confidence interval [CI] 1.45-2.22) and 1.35-fold (95% CI 1.12-1.63) higher risk of decline in ADL and IADL, respectively (p for t...Continue Reading

Citations

Jul 3, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Giulia OgliariRudi G J Westendorp
Aug 16, 2016·Journal of Neuropathology and Experimental Neurology·Lilah M BesserWalter A Kukull
Nov 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joshua Coulter RussellAlexander Mendenhall
Oct 20, 2018·Pediatric Exercise Science·Vinícius Y B SuetakeDiego G D Christofaro
Jun 21, 2020·Sensors·Francisco M Garcia-MorenoMaría José Rodríguez-Fórtiz
Sep 17, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Galit WeinsteinDavid Tanne
Aug 28, 2020·Frontiers in Physiology·Leandro de Oliveira Sant'AnaHenning Budde
Aug 28, 2020·International Journal of Environmental Research and Public Health·Andrea AlbergoniFrancesco Sartor
May 12, 2016·Experimental and Therapeutic Medicine·Jin-Guo Dong
Feb 12, 2019·Journal of Strength and Conditioning Research·Jhennyfer A L RodriguesCarlos R B Júnior
Jul 8, 2021·Journal of cardiology·Kensuke NakamuraHideo Yasunaga
Aug 10, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Tristan W DoreyRobert A Rose

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