Resting heart rate in children with Crimean-Congo hemorrhagic fever: a tool to identify patients at risk?

Vector Borne and Zoonotic Diseases
Mehmet Burhan OflazFusun Dilara Içağasioğlu

Abstract

We aimed to assess the association between resting heart rate (RHR) and severe infection in children with Crimean-Congo hemorrhagic fever (CCHF). In all, 121 patients under 18 years of age with a laboratory-confirmed diagnosis of CCHF were enrolled in the study. Patients were classified into two groups based on disease severity (severe group and nonsevere group). RHR was measured by electrocardiography (ECG) on admission. Maximum P-wave duration (Pmax), P-wave dispersion (Pd), QRS duration, corrected QT interval, and QT dispersion were also measured. Mean age was 11.4±3.9 years and 84 patients were male. Twenty-six patients were classified as severe. Patients in this group had a higher RHR (103.6±10.4 vs. 80.5±8.1, p=0.001) than those with nonsevere disease. There was no difference in Pmax, Pd, QRS duration, QTcmax, or QTc dispersion. The optimal cutoff value of RHR to predict disease severity was>96 beats per minute (bpm), with 70.6% sensitivity and 50.1% specificity. Bleeding, thrombocytopenia (≤80×10(9)/L), elevated aspartate transaminase (AST) (>208 IU/L), elevated alanine transaminase (ALT) (>87 IU/L), elevated lactate dehydrogenase (LDH) (>566 IU/L), long activated partial thromboplastin time (aPTT) (>42 s), and increased...Continue Reading

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Citations

Sep 9, 2015·Vector Borne and Zoonotic Diseases·Belgin GülhanHasan Tezer
Jan 4, 2015·Ticks and Tick-borne Diseases·Zeynep Gokce Gayretli AydinZeynep Gençtürk

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
biopsy

Software Mentioned

SPSS

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