Resting hypofrontality in schizophrenia: A study using near-infrared time-resolved spectroscopy

Schizophrenia Research
Yoko HoshiNagafumi Doi

Abstract

Hypofrontality has been a major finding obtained from functional neuroimaging studies on schizophrenia, although there have also been contradictory results that have questioned the reality of hypofrontality. In our previous study, we confirmed the existence of activation hypofrontality by using a 2-channel continuous-wave-type (CW-type) near-infrared spectroscopy (NIRS) instrument. In this study, we employed a single-channel time-resolved spectroscopy (TRS) instrument, which can quantify hemoglobin (Hb) concentrations based on the photon diffusion theory, to investigate resting hypofrontality. A pair of incident and detecting light guides was placed on either side of the forehead at approximately Fp2-F8 or Fp1-F7 alternately in 14 male schizophrenic patients and 16 age-matched male control subjects to measure Hb concentrations at rest. The patients were also measured with a 2-channel CW-type NIRS instrument during the performance of a random number generation (RNG) task. A reduced total hemoglobin concentration (t-Hb) less than 60 microM (the mean value of the control subjects-1.5 SD) was observed bilaterally in 4 patients and only in the left side in 3 patients. Activation hypofrontality was more manifest in these patients tha...Continue Reading

References

Dec 1, 1992·Archives of General Psychiatry·A WolkinJ Rotrosen
Feb 1, 1990·Brain : a Journal of Neurology·K L LeendersS Herold
Feb 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·M S BuchsbaumS Guich
Dec 1, 1988·Physics in Medicine and Biology·D T DelpyJ Wyatt
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B ChanceM Young
Jan 1, 1974·Acta Psychiatrica Scandinavica·D H Ingvar, G Franzén
Sep 1, 1974·Stroke; a Journal of Cerebral Circulation·R L GrubbM M Ter-Pogossian
Jul 1, 1984·Stroke; a Journal of Cerebral Circulation·P PantanoD Comar
Feb 1, 1984·The American Journal of Psychiatry·M A Taylor, R Abrams
Oct 1, 1982·Archives of General Psychiatry·R J MathewD L Barr
Jan 1, 1980·Stroke; a Journal of Cerebral Circulation·E MelamedY Rinot
Nov 1, 1995·The American Journal of Psychiatry·N C AndreasenR D Hichwa
Apr 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·K P EbmeierG M Goodwin
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T KatoT Ozaki
Oct 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D R Weinberger, K F Berman
Jul 1, 1997·Brain Research. Cognitive Brain Research·A J FallgatterW K Strik
Mar 30, 2001·Cerebral Cortex·Y HirayasuR W McCarley
Jan 21, 2004·Biological Psychiatry·Toshikazu ShinbaYoko Hoshi
Sep 9, 2004·Acta Psychiatrica Scandinavica·K HillP J McKenna
Dec 31, 2004·The American Journal of Psychiatry·Laura C WiegandMartha E Shenton
May 3, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Colm McDonaldRobin M Murray

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Citations

Feb 19, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shinsuke KoikeKiyoto Kasai
Sep 23, 2008·Medical Hypotheses·Wolfgang SperlingUdo Reulbach
Apr 13, 2013·NeuroImage·Ann-Christine EhlisAndreas J Fallgatter
Jun 12, 2013·NeuroImage·Alessandro TorricelliLorenzo Spinelli
Jan 30, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Natalya A UranovaDiana D Orlovskaya

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