Resting plasma membrane potential of rat peritoneal mast cells is set predominantly by the sodium pump.

FEBS Letters
C BronnerY Landry

Abstract

Changes in the plasma membrane potential of two histamine-releasing cells, rat peritoneal mast cells and basophilic leukemia cells 2H3 (RBL 2H3), were recorded with the potential-sensitive dye bis-oxonol. For mast cells, the presence of ouabain or the absence of K+ increased the fluorescence intensity of bis-oxonol; gramicidin had no effect. For RBL 2H3 cells, the presence of ouabain and the absence of K+ also increased bis-oxonol fluorescence but gramicidin also increased it. These results show that the plasma membrane potential of RBL 2H3 cells is set, in part, by the activity of the Na+ pump and in part by the K+ conductance, while that of rat mast cells is set predominantly by the Na+ pump.

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T IshizakaK Ishizaka
Jul 11, 1985·Biochimica Et Biophysica Acta·C L Bashford, C A Pasternak
Apr 1, 1989·British Journal of Pharmacology·T Knudsen, T Johansen
Mar 1, 1987·The Journal of Cell Biology·F C Mohr, C Fewtrell
Apr 1, 1988·Canadian Journal of Physiology and Pharmacology·C Barajas-López, J D Huizinga
Jan 1, 1983·The Journal of Membrane Biology·R Sagi-Eisenberg, I Pecht
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B I Kanner, H Metzger
Jan 1, 1984·The Journal of Membrane Biology·C L Bashford, C A Pasternak

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Citations

May 1, 1991·Agents and Actions·M R VieytesL M Botana
Oct 15, 1998·Life Sciences·A G CabadoL M Botana
Jan 10, 1998·British Journal of Pharmacology·U G FriisT Johansen
Apr 30, 2014·Annual Review of Biophysics·Adam E Cohen, Veena Venkatachalam
Mar 1, 1997·The American Journal of Physiology·Y H WangJ Y Wei
Oct 3, 2001·Physiological Reviews·H G Glitsch
Aug 25, 2020·Toxicology and Applied Pharmacology·Suraj SangroulaJulie A Gosse
Dec 9, 1991·Biochimica Et Biophysica Acta·C Bronner, Y Landry
Apr 14, 2021·Canadian Journal of Physiology and Pharmacology·Adeola Temitope SalamiSamuel Babafemi Olaleye

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