Abstract
To evaluate deficits of delayed free recall in euthymic older patients with bipolar disorder and relate deficits to resting cerebral metabolism. Two group, between subjects. Outpatient. Participants included 16 older adult (mean age, 58.7 years; SD = 7.5) euthymic outpatients with bipolar disorder (10 Type I and 6 Type II) and 11 healthy comparison subjects (mean age, 58.3 years; SD = 5.2). All participants received resting positron emission tomography with (18)flurodeoxyglucose and, within 10 days, delayed free verbal recall testing with the California Verbal Learning Test II. Patients with bipolar disorder, relative to healthy comparison subjects, had significantly poorer delayed free verbal recall. In patients with bipolar disorder, relative to healthy comparison subjects, prefrontal hypometabolism (dorsolateral prefrontal cortex) and paralimbic hypermetabolism (hippocampus, parahippocampal gyrus, and superior temporal gyrus) was associated with recall deficits in patients with bipolar disorder. Prefrontal and limbic metabolism were inversely related. Our findings demonstrate an association between prefrontal hypometabolism and paralimbic hypermetabolism and verbal memory deficits in euthymic older patients with bipolar diso...Continue Reading
References
Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Sep 1, 1996·Psychological Bulletin·R L West
Jul 17, 1999·Human Brain Mapping·J Ashburner, K J Friston
Aug 25, 1999·Biological Psychiatry·W G van GorpJ Mintz
Feb 7, 2003·Neuropsychobiology·A Martinez-AranM Salamero
Aug 10, 2005·Neurology·B C DickersonR A Sperling
Sep 20, 2005·Biological Psychiatry·Thilo DeckersbachScott L Rauch
Feb 3, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ariel G GildengersBenoit H Mulsant
Jul 10, 2007·Biological Psychiatry·T William J MoorheadAndrew M McIntosh
Sep 18, 2007·Psychiatry Research·Lori L AltshulerJim Mintz
Feb 5, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·C Thomas Gualtieri, Lynda G Johnson
Feb 5, 2008·The American Journal of Psychiatry·Mary L PhillipsDavid J Kupfer
Feb 22, 2008·Journal of Affective Disorders·Rafael Tabarés-SeisdedosEduard Vieta
Feb 23, 2008·Journal of Affective Disorders·N AgarwalP Brambilla
Oct 25, 2008·Journal of Psychiatric Research·John O BrooksTerence A Ketter
Citations
Feb 27, 2013·PloS One·Emily J KnightKendall H Lee
Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ivan AprahamianPaula V Nunes
Sep 11, 2012·Psychiatry Research·Laura Moreno-LópezAntonio Verdejo-García
Sep 23, 2011·Journal of Psychiatric Research·Martin BaresCyril Höschl
Jun 17, 2011·Psychiatry Research·David A Kupferschmidt, Konstantine K Zakzanis
Jan 19, 2010·Psychiatry Research·John O BrooksTerence A Ketter
Nov 26, 2009·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Robert C Young, Kenneth I Shulman
Dec 24, 2010·Bipolar Disorders·John O BrooksTerence A Ketter
May 9, 2013·Bipolar Disorders·Cecilia SamaméSergio A Strejilevich
Nov 22, 2012·Bipolar Disorders·Cheng-Ta LiTung-Ping Su
Oct 10, 2013·Bipolar Disorders·Allison C NugentCarlos A Zarate
Oct 25, 2008·Journal of Psychiatric Research·John O BrooksTerence A Ketter
Jul 13, 2014·Journal of Psychiatric Research·John O Brooks, Nathalie Vizueta
Aug 29, 2014·Bipolar Disorders·Viola Oertel-KnöchelDavid Ej Linden
Mar 21, 2013·Journal of Affective Disorders·Maria Stylianou KorsnesUlrik Fredrik Malt
Nov 9, 2019·BMC Pulmonary Medicine·Minmin YinYongqiang Yu