Resting prefrontal hypometabolism and paralimbic hypermetabolism related to verbal recall deficits in euthymic older adults with bipolar disorder

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
John O BrooksTerence A Ketter

Abstract

To evaluate deficits of delayed free recall in euthymic older patients with bipolar disorder and relate deficits to resting cerebral metabolism. Two group, between subjects. Outpatient. Participants included 16 older adult (mean age, 58.7 years; SD = 7.5) euthymic outpatients with bipolar disorder (10 Type I and 6 Type II) and 11 healthy comparison subjects (mean age, 58.3 years; SD = 5.2). All participants received resting positron emission tomography with (18)flurodeoxyglucose and, within 10 days, delayed free verbal recall testing with the California Verbal Learning Test II. Patients with bipolar disorder, relative to healthy comparison subjects, had significantly poorer delayed free verbal recall. In patients with bipolar disorder, relative to healthy comparison subjects, prefrontal hypometabolism (dorsolateral prefrontal cortex) and paralimbic hypermetabolism (hippocampus, parahippocampal gyrus, and superior temporal gyrus) was associated with recall deficits in patients with bipolar disorder. Prefrontal and limbic metabolism were inversely related. Our findings demonstrate an association between prefrontal hypometabolism and paralimbic hypermetabolism and verbal memory deficits in euthymic older patients with bipolar diso...Continue Reading

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Oct 25, 2008·Journal of Psychiatric Research·John O BrooksTerence A Ketter

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Citations

Apr 10, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ivan AprahamianPaula V Nunes
Jan 19, 2010·Psychiatry Research·John O BrooksTerence A Ketter
Nov 26, 2009·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Robert C Young, Kenneth I Shulman
May 9, 2013·Bipolar Disorders·Cecilia SamaméSergio A Strejilevich
Oct 10, 2013·Bipolar Disorders·Allison C NugentCarlos A Zarate
Oct 25, 2008·Journal of Psychiatric Research·John O BrooksTerence A Ketter
Jul 13, 2014·Journal of Psychiatric Research·John O Brooks, Nathalie Vizueta
Mar 21, 2013·Journal of Affective Disorders·Maria Stylianou KorsnesUlrik Fredrik Malt

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