Resting State and Diffusion Neuroimaging Predictors of Clinical Improvements Following Constraint-Induced Movement Therapy in Children With Hemiplegic Cerebral Palsy

Journal of Child Neurology
Kathryn Y ManningRavi S Menon

Abstract

The aim was to identify neuroimaging predictors of clinical improvements following constraint-induced movement therapy. Resting state functional magnetic resonance and diffusion tensor imaging data was acquired in 7 children with hemiplegic cerebral palsy. Clinical and magnetic resonance imaging (MRI) data were acquired at baseline and 1 month later following a 3-week constraint therapy regimen. A more negative baseline laterality index characterizing an atypical unilateral sensorimotor resting state network significantly correlated with an improvement in the Canadian Occupational Performance Measure score (r = -0.81, P = .03). A more unilateral network with decreased activity in the affected hemisphere was associated with greater improvements in clinical scores. Higher mean diffusivity in the posterior limb of the internal capsule of the affect tract correlated significantly with improvements in the Jebsen-Taylor score (r = -0.83, P = .02). Children with more compromised networks and tracts improved the most following constraint therapy.

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Citations

Nov 14, 2015·Neurorehabilitation and Neural Repair·Mitchell SchertzDido Green
Apr 2, 2019·The Cochrane Database of Systematic Reviews·Brian J HoareChristine Imms
Jul 31, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Brandon T CraigHelen L Carlson
Jun 16, 2021·Nature Reviews. Neurology·Adam KirtonHelen L Carlson

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Software Mentioned

Diffusion Toolbox
Linear Image Registration Tool
Statistical Product and Service Solutions ( SPSS )
Hand2Hand
fsl
functional MRI Expert Analysis Tool

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