Resting state BOLD functional connectivity at 3T: spin echo versus gradient echo EPI

PloS One
Piero Chiacchiaretta, Antonio Ferretti

Abstract

Previous evidence showed that, due to refocusing of static dephasing effects around large vessels, spin-echo (SE) BOLD signals offer an increased linearity and promptness with respect to gradient-echo (GE) acquisition, even at low field. These characteristics suggest that, despite the reduced sensitivity, SE fMRI might also provide a potential benefit when investigating spontaneous fluctuations of brain activity. However, there are no reports on the application of spin-echo fMRI for connectivity studies at low field. In this study we compared resting state functional connectivity as measured with GE and SE EPI sequences at 3T. Main results showed that, within subject, the GE sensitivity is overall larger with respect to that of SE, but to a less extent than previously reported for activation studies. Noteworthy, the reduced sensitivity of SE was counterbalanced by a reduced inter-subject variability, resulting in comparable group statistical connectivity maps for the two sequences. Furthermore, the SE method performed better in the ventral portion of the default mode network, a region affected by signal dropout in standard GE acquisition. Future studies should clarify if these features of the SE BOLD signal can be beneficial to...Continue Reading

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Citations

Sep 18, 2015·Frontiers in Human Neuroscience·Laura F MegaKirsten G Volz
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Nov 24, 2018·Frontiers in Human Neuroscience·Ke ZhangN Jon Shah
Nov 29, 2016·Frontiers in Neuroscience·José M SoaresNuno Sousa
Sep 4, 2021·NeuroImage·Luisa RaimondoWietske van der Zwaag

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Methods Mentioned

BETA
SMA
imaging technique

Software Mentioned

ANATICOR
GE
FreeSurfer
RetroTS
AFNI
3dDespike
AlphaSim
RETROICOR

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