Resting-state connectivity and spontaneous activity of ventromedial prefrontal cortex predict depressive symptomology and peripheral inflammation in HIV

Journal of Neurovirology
Roger C McIntoshKalpana J Kallianpur

Abstract

Depression and chronic inflammation are common in persons infected with the human immunodeficiency virus (HIV+). Although depression and response to inflammatory challenge are shown to reflect activity in common neural networks, little is known regarding sub-clinical presentation in persons chronically infected with HIV. The relationship of resting-state functional connectivity (rsFC) between the subgenual anterior cingulate cortex (sgACC) and bilateral amygdala to Beck Depression Inventory-1 (BDI) scores were compared within a group of 23 HIV+ and 23 HIV-negative comparison adults. An interaction was found wherein lower rsFC between the sgACC and both right and left amygdala was associated with higher BDI scores in HIV+ individuals. Total BDI scores and plasma levels of IL-6, IL-8, TNF-α, and IL-10 made available from 10 of the HIV+ patients were regressed upon an index of spontaneous whole-brain activity at rest; i.e., the amplitude of low-frequency fluctuations (ALFFs). Elevated levels of depression and IL-6 were associated with increased ALFF in a cluster of voxels on the medial portion of the ventral surface of the frontal lobe (Brodmann Area 11). Within this sample of HIV+ individuals lower rsFC of the sgACC with subcorti...Continue Reading

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Citations

Jan 29, 2020·Journal of Neurovirology·Carissa L PhilippiUNKNOWN SEARCH 010/RV254 and RV304/SEARCH 013 study teams
Sep 22, 2020·Brain and Neuroscience Advances·Kristian StefanovRajeev Krishnadas
Jun 6, 2021·Human Brain Mapping·Margarita BronshteynXiong Jiang
Nov 19, 2021·Current HIV/AIDS Reports·Jacqueline HoareNicole Phillips

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
blood draw

Software Mentioned

SPM12
3dmaskave
ALFF
3dfim
AFNI

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