Resting-State Connectivity Biomarkers of Cognitive Performance and Social Function in Individuals With Schizophrenia Spectrum Disorder and Healthy Control Subjects

Biological Psychiatry
Joseph D VivianoSocial Processes Initiative in Neurobiology of the Schizophrenia(s) Group

Abstract

Deficits in neurocognition and social cognition are drivers of reduced functioning in schizophrenia spectrum disorders, with potentially shared neurobiological underpinnings. Many studies have sought to identify brain-based biomarkers of these clinical variables using a priori dichotomies (e.g., good vs. poor cognition, deficit vs. nondeficit syndrome). We evaluated a fully data-driven approach to do the same by building and validating a brain connectivity-based biomarker of social cognitive and neurocognitive performance in a sample using resting-state and task-based functional magnetic resonance imaging (n = 74 healthy control participants, n = 114 persons with schizophrenia spectrum disorder, 188 total). We used canonical correlation analysis followed by clustering to identify a functional connectivity signature of normal and poor social cognitive and neurocognitive performance. Persons with poor social cognitive and neurocognitive performance were differentiated from those with normal performance by greater resting-state connectivity in the mirror neuron and mentalizing systems. We validated our findings by showing that poor performers also scored lower on functional outcome measures not included in the original analysis an...Continue Reading

Citations

Jun 28, 2020·Human Brain Mapping·Xiaowei ZhuangDietmar Cordes
Sep 12, 2020·Schizophrenia Bulletin·Gonzalo Salazar de PabloPaolo Fusar-Poli
Feb 14, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Lindsay D OliverUNKNOWN SPINS Group
Jan 8, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sugai LiangTao Li
Mar 14, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Yachen ShiUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 9, 2019·Biological Psychiatry·Daniel P Eisenberg, Karen F Berman
Apr 7, 2021·Schizophrenia Bulletin·Maria R DauvermannGary Donohoe

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