Resting-state Dynamics as a Cortical Signature of Anesthesia in Monkeys

Anesthesiology
Lynn UhrigBéchir Jarraya

Abstract

WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: The mechanism by which anesthetics induce a loss of consciousness remains a puzzling problem. We hypothesized that a cortical signature of anesthesia could be found in an increase in similarity between the matrix of resting-state functional correlations and the anatomical connectivity matrix of the brain, resulting in an increased function-structure similarity. We acquired resting-state functional magnetic resonance images in macaque monkeys during wakefulness (n = 3) or anesthesia with propofol (n = 3), ketamine (n = 3), or sevoflurane (n = 3). We used the k-means algorithm to cluster dynamic resting-state data into independent functional brain states. For each condition, we performed a regression analysis to quantify function-structure similarity and the repertoire of functional brain states. Seven functional brain states were clustered and ranked according to their similarity to structural connectivity, with higher ranks corresponding to higher function-structure similarity and lower ranks corresponding to lower correlation between brain function and brain anatomy. Anesthesia shifted the brain state composition from a low rank (rounded rank [mean ± SD]) in the awake condit...Continue Reading

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Citations

Aug 14, 2018·Anesthesiology·George A Mashour
Feb 27, 2019·Anesthesiology·George A Mashour
Oct 9, 2019·Topics in Magnetic Resonance Imaging : TMRI·András Jakab
Sep 10, 2019·Anesthesia and Analgesia·Michael A FrölichAdrienne C Lahti
Apr 5, 2019·Anesthesiology·Phillip E VlisidesGeorge A Mashour
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Mar 15, 2019·Anesthesiology·George A Mashour
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Sep 3, 2019·Frontiers in Systems Neuroscience·Vincent BonhommeOlivia Gosseries
Feb 11, 2020·Frontiers in Neuroinformatics·Francesca MandinoJoanes Grandjean
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Oct 27, 2020·Cognitive Neurodynamics·Eva Déli, Zoltán Kisvárday
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Jan 3, 2022·Cerebral Cortex·Camille GiacomettiCéline Amiez

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