Resting state fMRI correlates of Theory of Mind impairment in amyotrophic lateral sclerosis

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Francesca TrojsiGioacchino Tedeschi

Abstract

Theory of Mind (ToM), the ability to recognize thoughts and emotions of another, may be one of the cognitive domains affected in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease now recognized as a multi-system disorder. The present study aimed to identify early dysfunctions of brain resting state functional magnetic resonance imaging (RS-fMRI) networks in a group of ALS patients longitudinally explored for impairment of "cognitive" and "affective" ToM subcomponents. RS-fMRI connectivity was investigated in a group of 21 patients with ALS (i.e., 9 with bulbar-onset or ALS-B and 12 with limb-onset or ALS-L) in early stages of disease and 15 healthy controls (HCs). The same subjects were assessed, at baseline and after six months, for neuropsychological performances, including cognitive and affective ToM and multi-domain cognitive functions. The RS-fMRI study showed a decreased connectivity in frontotemporal areas within the main cognitive resting state networks, including the default mode (DMN), the right and left fronto-parietal (R-, L-FPN), and the salience (SLN) networks, in the entire ALS group. As exploratory results, comparing the ALS-B subgroup to the ALS-L one, we revealed a widespread decrease of RS-fMRI...Continue Reading

Citations

Aug 17, 2020·Journal of Clinical Medicine·Alexander SteinkeBruno Kopp
Aug 28, 2020·Frontiers in Neuroscience·Corentin ValléeChristian Barillot
Mar 28, 2019·Frontiers in Neuroscience·Elisabetta ZucchiJessica Mandrioli
Mar 3, 2020·Frontiers in Behavioral Neuroscience·Alvino BiseccoAntonio Gallo
Jan 24, 2019·Frontiers in Neurology·Malcolm ProudfootMartin R Turner
Nov 20, 2021·Journal of Neurology·Maria Antonietta MagnoFederica Agosta

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