Resting-state functional connectivity between the dorsal anterior cingulate cortex and thalamus is associated with risky decision-making in nicotine addicts

Scientific Reports
Zhengde WeiXiaochu Zhang

Abstract

Nicotine addiction is associated with risky behaviors and abnormalities in local brain areas related to risky decision-making such as the dorsal anterior cingulate cortex (dACC), anterior insula (AI), and thalamus. Although these brain abnormalities are anatomically separated, they may in fact belong to one neural network. However, it is unclear whether circuit-level abnormalities lead to risky decision-making in smokers. In the current study, we used task-based functional magnetic resonance imaging (fMRI) and examined resting-state functional connectivity (RSFC) to study how connectivity between the dACC, insula, and thalamus influence risky decision-making in nicotine addicts. We found that an increase in risky decision-making was associated with stronger nicotine dependence and stronger RSFC of the dACC-rAI (right AI), the dACC-thalamus, the dACC-lAI (left AI), and the rAI-lAI, but that risky decision-making was not associated with risk level-related activation. Furthermore, the severity of nicotine dependence positively correlated with RSFC of the dACC-thalamus but was not associated with risk level-related activation. Importantly, the dACC-thalamus coupling fully mediated the effect of nicotine-dependent severity on risky ...Continue Reading

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Citations

Oct 8, 2016·Frontiers in Psychology·Zhiling ZouXiaochu Zhang
Feb 15, 2017·Journal of Psychiatric Research·Jason SmucnyJason R Tregellas
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Jul 6, 2016·Scientific Reports·Zhengjun LiZe Wang
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Apr 8, 2020·Frontiers in Psychiatry·Adellah SariahXiaojun Huang
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Feb 23, 2020·Drug and Alcohol Dependence·Ranjita PoudelMatthew T Sutherland

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Software Mentioned

FAST
Functional MRI of the Brain
MATLAB
AFNI [ Analysis of Functional Neuroimages

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