Resting-State Functional Connectivity Dynamics in Healthy Aging: An Approach Through Network Change Point Detection.

Brain Connectivity
Núria Mancho-ForaJoan Guàrdia-Olmos

Abstract

This study aims at assessing the impact of age on the short-term temporal dynamics of the topological properties of the undirected and weighted whole-brain functional connectivity (FC) networks. We studied the association between the participant's age and the number of significant change points detected through the Network Change Point Detection algorithm. Secondary, we defined state as the resting-state functional magnetic resonance imaging (rs-fMRI) subsequence between two significant change points, obtaining the FC network in each state and participant and characterized their network topological properties. The data comprise the rs-fMRI sequences of 114 healthy individuals combined from 3 different studies conducted at the Department of Medicine, School of Medicine and Health Sciences, University of Barcelona. Participants were healthy people in the absence of any pathology that could interfere with the scanning procedures, as well as any chronic illness that implied a short-lived situation. Topological properties of everyone's FC networks were characterized by their network strength, transitivity, characteristic path length, and small-worldness, analyzing the effect of age in those observed distributions. To that effect, we...Continue Reading

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NetworkToolbox R
FSL ( FMRIB Software Library

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