Resting-state functional connectivity abnormalities correlate with psychometric hepatic encephalopathy score in cirrhosis

European Journal of Radiology
Hua-Jun ChenHai-Bin Shi

Abstract

Neurocognitive impairment is a common complication of cirrhosis and regarded as the important characteristic for early stage of hepatic encephalopathy (HE). This study aimed to investigate the changes in brain network centrality of functional connectivity among cirrhotic patients and uncover the mechanisms about early HE. Twenty-four cirrhotic patients without overt HE and 21 healthy controls were enrolled and underwent resting-state fMRI and Psychometric Hepatic Encephalopathy Score (PHES) tests. Whole-brain functional network was constructed by measuring the temporal correlations of every pairs of brain gray matter voxels; and then voxel-wise degree centrality (DC), an index reflecting importance of a node in functional integration, was calculated and compared between two groups. A seed-based resting-state functional connectivity (RSFC) analysis was further performed to investigate abnormal functional connectivity pattern of those regions with changed DC. Compared with controls, the cirrhotic patients had worse performances in all neurocognitive tests and lower PHES score. Meanwhile, patients showed decreased DC in bilateral medial prefrontal gyrus and anterior cingulate cortex, left middle frontal gyrus, and bilateral thalam...Continue Reading

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Citations

Jul 28, 2016·Frontiers in Aging Neuroscience·Yu-Chen ChenXindao Yin
Jan 28, 2018·Metabolic Brain Disease·Xiao Dong Zhang, Long Jiang Zhang
Mar 16, 2021·Frontiers in Neuroanatomy·Hua-Jun ChenRong Chen

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