PMID: 179093May 1, 1976

Resting state in normal and simian virus 40 transformed Chinese hamster lung cells

Proceedings of the National Academy of Sciences of the United States of America
R G Martin, S Stein

Abstract

Normal cell deprived of amino acids or serum factors enter a resting state, whereas cells transformed by wild-type simian virus 40 do not. The ability to enter a resting state is temperature-sensitive (ts) in cells transformed by a tsA mutant of simian virus 40. We shown further: (i) that when complete medium is added to resting cells, the length of time until the onset of DNA synthesis often exceeds the length of G1 in growing cells; (ii) that the length of this interval depends upon the conditions used to arrest cell growth; but (iii) that transferring cultures from medium depleted for one factor to medium depleted in a second factor never leads to a round of DNA synthesis; and (iv) that DNA synthesis does not resume rapidly when a resting culture of cells transformed by the tsA mutant is transferred to the permissive temperature in suboptimal medium. A model proposing that in suboptimal conditions cells leave the cell cycle and traverse a branch pathway to enter the resting state is consistent with these findings.

References

Jan 1, 1975·Cold Spring Harbor Symposia on Quantitative Biology·D Baltimore
Feb 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G Kimura, A Itagaki
Jan 1, 1975·Cold Spring Harbor Symposia on Quantitative Biology·R G MartinR Saral
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·D G TenenD M Livingston
Dec 1, 1974·Journal of Cellular Physiology·S J BurstinC Basilico
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J A Smith, L Martin
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·A B Pardee
Oct 1, 1972·Journal of Cellular Physiology·G Sander, A B Pardee

Citations

Jan 1, 1983·The Journal of Membrane Biology·R PanetA Alayoff
Feb 1, 1981·In Vitro·H GershmanD A Carrino
Aug 10, 1979·Biochimica Et Biophysica Acta·C D ScherC D Stiles
Aug 31, 1981·Biochimica Et Biophysica Acta·R Hand
Jul 20, 2007·Nature Reviews. Molecular Cell Biology·Hilary A Coller
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C C Robinson, J M Lehman
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P V CheringtonA B Pardee
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P W RossowA B Pardee
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R M Hoffman, S J Jacobsen
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R G Croy, A B Pardee
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D H PluznikP D Noguchi
Jan 1, 1979·Preparative Biochemistry·E Bollin, E Sulkowski
Jun 1, 1977·Experimental Cell Research·J Hassell, D L Engelhardt
Jul 1, 1984·Cell and Tissue Kinetics·J M NelsonN F Metting
Oct 4, 1979·Nature·C D ScherC D Stiles
Apr 1, 1984·Journal of Cellular Physiology·H Zaitsu, G Kimura
Dec 1, 1978·Journal of Cellular Physiology·A Talavera, C Basilico
Mar 15, 1982·International Journal of Cancer. Journal International Du Cancer·H R SouleJ S Butel

Related Concepts

Cell Division Phases
Neoplastic Cell Transformation
DNA, Double-Stranded
Simian virus 40

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