Resting-state theta band connectivity and graph analysis in generalized social anxiety disorder

NeuroImage. Clinical
Mengqi XingHeide Klumpp


Functional magnetic resonance imaging (fMRI) resting-state studies show generalized social anxiety disorder (gSAD) is associated with disturbances in networks involved in emotion regulation, emotion processing, and perceptual functions, suggesting a network framework is integral to elucidating the pathophysiology of gSAD. However, fMRI does not measure the fast dynamic interconnections of functional networks. Therefore, we examined whole-brain functional connectomics with electroencephalogram (EEG) during resting-state. Resting-state EEG data was recorded for 32 patients with gSAD and 32 demographically-matched healthy controls (HC). Sensor-level connectivity analysis was applied on EEG data by using Weighted Phase Lag Index (WPLI) and graph analysis based on WPLI was used to determine clustering coefficient and characteristic path length to estimate local integration and global segregation of networks. WPLI results showed increased oscillatory midline coherence in the theta frequency band indicating higher connectivity in the gSAD relative to HC group during rest. Additionally, WPLI values positively correlated with state anxiety levels within the gSAD group but not the HC group. Our graph theory based connectomics analysis de...Continue Reading


Feb 3, 2006·Cerebral Cortex·C J StamPh Scheltens
May 3, 2011·Magnetic Resonance Imaging·Jurong DingQiyong Gong
Aug 16, 2014·Neuroscience and Biobehavioral Reviews·Annette Beatrix BrühlSteffi Weidt
Dec 24, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Feng LiuHuafu Chen

❮ Previous
Next ❯


Nov 21, 2017·Journal of Integrative Neuroscience·Evgeniy A CheremushkinOlga V Sergeeva
Jan 23, 2020·The American Journal of Psychiatry·Russell T TollAmit Etkin
Jul 8, 2020·Physical and Engineering Sciences in Medicine·Sajjad Farashi, Reza Khosrowabadi
Mar 14, 2019·Prilozi·Silvana Markovska-SimoskaJordan Pop-Jordanov
Jan 29, 2019·Frontiers in Human Neuroscience·Jennifer J Newson, Tara C Thiagarajan
Jun 9, 2020·Frontiers in Psychology·Abdulhakim Al-EzziEsther Gunaseli
Jan 4, 2019·Journal of Affective Disorders·Claudio ImperatoriRita B Ardito
Dec 5, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tetsuya TakahashiYuji Wada
Jun 23, 2021·Applied Neuropsychology. Adult·Farhad TaremianSeyed Ruhollah Hosseini

❮ Previous
Next ❯

Software Mentioned

MATLAB Fieldtrip
Statistical Package for the Social Sciences
Brain Vision Analyzer

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.