Resting tremor only: a variant of Parkinson's disease or of essential tremor

Journal of the Neurological Sciences
M H ChangC G Sy

Abstract

Resting tremor is one of the characteristic features of Parkinson's disease. However, there are a number of patients who typically have resting tremor alone for at least 5 years without development of other parkinsonian signs or symptoms. The etiology of an isolated resting tremor is still obscure. Recently, positron emission tomography was used to study these patients with isolated resting tremor, and demonstrated a markedly decreased striatal uptake of fluoro-dopa to the range of Parkinson's disease. These findings suggested the existence of a separate subtype, namely, tremulous Parkinson's disease with a manifestation of resting tremor alone. In order to confirm the existence of this subgroup of tremulous Parkinson's disease and further investigate its morphological changes and the usefulness of magnetic resonance imaging, we collected 5 patients who typically have resting tremor for at least 8 years in the absence of other features of Parkinson's disease. MRI was performed and the results of the images showed typical findings of Parkinson's disease with smudging or decreased distance between substantia nigra and red nucleus. Quantitative analysis also demonstrated a significant decrease of the above-noted distance when the ...Continue Reading

References

Jun 1, 1992·Topics in Magnetic Resonance Imaging : TMRI·D G Mitchell
Dec 1, 1990·Neurology·A H RajputA H Rajput
Jan 1, 1989·AJR. American Journal of Roentgenology·B H BraffmanR A Zimmerman
Dec 1, 1986·Annals of Neurology·J R DuguidJ DeGroot
Jul 21, 2004·Parkinsonism & Related Disorders·Eun Ah LeeWon Yong Lee

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Citations

Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Mehran GhaemiWolf-Dieter Heiss
Jul 20, 2000·Parkinsonism & Related Disorders·I Milanov

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