Resting Whole Body Energy Metabolism in Class 3 Obesity; from Preserved Insulin Sensitivity to Overt Type 2 Diabetes

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
Giuseppina ManzoniGianluca Perseghin

Abstract

Insulin resistance and diabetes may influence separately or in combination whole body energy metabolism. To assess the impact of insulin resistance and/or overt type 2 diabetes on resting energy expenditure (REE) in class 3 obese individuals. Retrospective, cross-sectional analysis of a set of data about individuals attending the outpatients service of a single center of bariatric surgery between January 2015 and December 2017. We screened 382 patients in which abnormal thyroid function was excluded, and segregated them in three groups of subjects: patients with type 2 diabetes (T2DM; n=70), non-diabetic insulin-resistant patients with HOMA-IR ≥ 3 (n=236), non-diabetic insulin-sensitive patients with HOMA-IR < 3 (n=75). Resting energy expenditure (REE), body composition and insulin resistance assessed using indirect calorimetry, bioimpedance and HOMA-IR. Non-diabetic insulin-sensitive patients resulted to be younger, with lower BMI and higher prevalence of female subjects; meanwhile, non-diabetic but insulin-resistant patients and T2DM patients were not different in terms of anthropometric parameters. REE was higher in T2DM than in non-diabetic insulin-resistant and insulin-sensitive individuals when expressed as percent of the...Continue Reading

References

Nov 1, 1982·The American Journal of Clinical Nutrition·J A BaeckeJ E Frijters
Dec 15, 2006·Nature·Jean-Pierre Després, Isabelle Lemieux
Mar 1, 2007·Diabetes Care·Gianluca PerseghinLivio Luzi
May 28, 2008·Diabetologia·A D KarelisR Rabasa-Lhoret
Aug 13, 2008·Archives of Internal Medicine·Norbert StefanHans-Ulrich Häring
Jan 9, 2010·Biochimica Et Biophysica Acta·Sam Virtue, Antonio Vidal-Puig
Oct 27, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·V PrimeauR Rabasa-Lhoret
Jan 31, 2012·Trends in Endocrinology and Metabolism : TEM·D Samocha-BonetJ R Greenfield
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Norbert StefanMatthias B Schulze
Jan 3, 2015·The Journal of Clinical Investigation·Elisa FabbriniSamuel Klein
Jan 9, 2016·Reviews of Physiology, Biochemistry and Pharmacology·Hyoung Kyu KimJin Han
Jun 18, 2018·Clinical Nutrition ESPEN·Hayder Al-Domi, Alaa Al-Shorman
Jul 5, 2018·JAMA Internal Medicine·David S Ludwig, Cara B Ebbeling

❮ Previous
Next ❯

Citations

Nov 13, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·A CordeiroA Ramalho

❮ Previous
Next ❯

Methods Mentioned

BETA
urine collection

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.