Restituted gastric mucosa: tolerance against low luminal pH and restricted mucosal blood flow in the cat

Gastroenterology
J E GrönbechK Svanes

Abstract

This study examined the tolerance of gastric surface epithelium allowed to restitute for 90 min after damage produced by mucosal exposure to 2 M NaCl for 10 min. Cats were subjected to gastric luminal perfusion with saline at pH = 1.0 and reduction of celiac artery blood flow for 90 min. A flow reduction of 55%, as assessed by Doppler ultrasound flowmetry, was obtained by constriction of the celiac artery. These interventions alone did not produce lesions in nondamaged control cats, whereas exposure to 2 M NaCl immediately before flow reduction evoked extensive erosions as judged by gross examination and microscopy. Stomachs exposed to 2 M NaCl 90 min before flow reduction showed lesions that were clearly less in extent and number than in animals in which an intervening restitution period was not allowed. Topical dimethyl-prostaglandin E2 (50 micrograms/kg) increased the rate by which restituted surface cells were transformed to apparently normal cells. This study shows that the restituted gastric mucosa possesses a remarkably high tolerance against lowered blood flow in the presence of high luminal acidity.

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