PMID: 11898486Mar 20, 2002Paper

Restless legs syndrome: a sensorimotor disorder of sleep/wake motor regulation

Current Neurology and Neuroscience Reports
Wayne Hening

Abstract

Restless legs syndrome (RLS) remains an underappreciated sensorimotor disorder of sleep/wake regulation. It is one of the few sensorimotor disorders that is provoked by rest and that also follows a clear circadian pattern. Recent epidemiologic studies have verified that the condition is common in populations derived from the north and west of Europe, and have begun to uncover some of the genetic substrate of the disorder. New instruments have been developed to facilitate diagnosis and assessment of severity. The pathogenesis of the condition remains uncertain, but recent discoveries implicate areas of the nervous system from the spinal cord up to the basal ganglia. A current hypothesis undergoing vigorous exploration is that the condition results from a deficiency of dopaminergic function based on abnormalities of iron transport and storage. Therapeutically, studies have shown the dopamine agonists to be the most reliable treatment for severe cases, whereas other recent studies have successfully utilized a number of other medications, including levodopa, opioids, and anticonvulsants. New standards provide guidelines for management of RLS and make specific pharmacotherapeutic recommendations.

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Citations

Jan 16, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Kittisak SawanyawisuthJosé S Loredo
Jul 14, 2014·Journal of the Neurological Sciences·Yoon-Sang OhKwang-Soo Lee
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Jan 8, 2016·Clinical Therapeutics·D Onentia Oyieng'oGhada Bourjeily
Mar 18, 2008·Clinical Therapeutics·Carlos MartinezAnthony H V Schapira
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Dec 18, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Wayne A HeningRobert Yoakum

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