Restless legs syndrome: clinical experience with long-term treatment

Sleep Medicine
Sandra C ClavadetscherC L Bassetti

Abstract

There are limited data on long-term treatment efficacy, and almost none on predictors of treatment response in patients with restless legs syndrome (RLS). To assess: (1) long-term efficacy of RLS treatment in a clinical setting, (2) predictors of a good treatment response, and (3) the value of the RLS-severity score according to the criteria of the International Restless Legs Syndrome Study Group (IRLSSG). Over three years 70 patients (36 men, 34 women; mean age: 59 years; range: 29-79) with RLS were prospectively assessed. Diagnosis of RLS was made according to international criteria Severity of RLS symptoms was were assessed at the outset by the IRLSSG rating scale. Treatment was chosen individually according to clinical judgement. After a mean follow-up time of 16 months (range: 1-106 months) evolution of symptoms was assessed by both overall clinical impression and IRLSSG rating scale. Clinical characteristics and treatment effect were compared between patients never treated for RLS before this study ('naïve'=N-pts) and those with previous treatment ('treated'=T-pts). Predictors of treatment response were sought for comparing patients with good treatment response (good, better or much better on follow-up) and those with bad...Continue Reading

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Citations

Nov 10, 2010·Clinical Neuropharmacology·Ulf KallweitClaudio L Bassetti
Nov 16, 2007·Medicine·Arn H Eliasson, Christopher J Lettieri
Nov 1, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C R BaumannC L Bassetti
May 4, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Sudhansu Chokroverty
May 23, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Wolfgang H OertelKarin Stiasny-Kolster
May 29, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Claudia TrenkwalderMarco Zucconi
Jun 26, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Stephany Fulda, Thomas C Wetter
Dec 19, 2019·Journal of Clinical Medicine·Seetha LakshmananHarneet K Walia
Oct 19, 2010·Physiotherapy Theory and Practice·Ulrike H MitchellBill Myrer
Oct 28, 2010·Physiotherapy Theory and Practice·Ulrike H MitchellSterling C Hilton
Dec 18, 2008·The International Journal of Artificial Organs·G C Kosmadakis, J F Medcalf

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