Restless Legs Syndrome

Spinal Cord
F E Glasauer

Abstract

Restless Legs Syndrome (RLS) is a well-defined symptom complex and is frequently associated with sleep disturbance and a recognized family history. It occurs either as idiopathic RLS or in association with many medical, neurological or vascular disorders. The neurological examination and routine investigations in idiopathic RLS are normal. Polysomnography supports the diagnosis of RLS by documenting the associated sleep disturbances and periodic limb movements in sleep (PLMS). Although MRI studies disclose no intracerebral lesions, recent Positron Emission Tomography (PET) and single photon emission computed tomography (SPECT) studies point to some involvement of the basal and red nuclei and the cerebellum. No definitive etiology is known for this condition, but several pathophysiological mechanisms have been proposed. There is supportive evidence that RLS is a Central Nervous System (CNS) dysfunction, suggesting widespread involvement of the descending dopaminergic (DA) pathways, possibly originating in the diencephalon or upper brainstem. This is corroborated by the successful treatment of RLS with DA agents, sedatives, and neurotransmitters. However, RLS can also occur with spinal disorders and spinal cord lesions implying t...Continue Reading

Citations

Mar 23, 2004·Sleep Medicine·G PaulettoP Bergonzi
Oct 24, 2003·Disease-a-month : DM·Peter Jacobs, Lucille Wood
Nov 1, 2003·Sleep Medicine·D Garcia-BorregueroY de la Llave
Apr 25, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Norman WolkoveMark Palayew
Jun 10, 2011·Neuropsychiatric Disease and Treatment·Ulrike H Mitchell
Aug 22, 2008·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Yuksel KaplanSerpil Ocal
Oct 19, 2010·Physiotherapy Theory and Practice·Ulrike H MitchellBill Myrer
Apr 1, 2008·The Diabetes Educator·Norma G Cuellar, Sarah J Ratcliffe
Jan 15, 2010·Medical Hypotheses·Melita J Giummarra, John L Bradshaw
Jul 22, 2008·Arquivos de neuro-psiquiatria·Fábio Galvão DantasClarissa Dantas Ribeiro
Feb 22, 2012·PloS One·Xugao WangZuoqiang Yuan

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