Restless Legs Syndrome/Willis-Ekbom Disease and Pregnancy

Sleep Medicine Clinics
Chiara Prosperetti, Mauro Manconi

Abstract

Restless legs syndrome (RLS)/Willis-Ekbom disease is 3-fold more prevalent in pregnant than in non-pregnant women. Symptoms are particularly strong and frequent during the third trimester of pregnancy and disappear around delivery. A pre-existing form of RLS tends to worsen during pregnancy. Women who experience RLS during pregnancy have a higher risk of symptoms in further pregnancies and of developing a primary form of RLS later in life, than women free of symptoms during pregnancy. This article reviews the literature for pregnancy-related RLS, with particular attention to its epidemiology, course, possible mechanisms, management, and the impact of symptoms.

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Jul 22, 2016·MMW Fortschritte der Medizin·Elisabeth HertensteinDieter Riemann
Jun 16, 2017·Drugs·Susan E Mackie, John W Winkelman
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Nov 5, 2021·Nature Reviews. Disease Primers·Mauro ManconiYves Dauvilliers

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