Abstract
Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) has a significant negative effect on quality of life. The decreased quality of life is similar to that of other chronic diseases, such as diabetes type 2, depression, and osteoarthritis. RLS/WED disrupts sleep length, sleep quality, and daytime alertness. Sleep disruption can contribute to depression. RLS/WED has been associated with cardiovascular disease and high blood pressure, possibly because of increased sympathetic tone caused by periodic limb movements of sleep. RLS/WED is underdiagnosed, leading to chronic sleep disruption and daytime consequences. Patients with RLS/WED have decreased productivity at work, which potentially has far-reaching economic consequences.
References
Oct 1, 1995·The Journal of Clinical Investigation·V K SomersF M Abboud
Jan 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·J MontplaisirP Lespérance
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
May 29, 2004·Sleep Medicine·Wayne HeningLuigi Ferini-Strambi
Jul 21, 2004·Clinical Therapeutics·Linda AbetzHelen Knight
Jun 16, 2005·Archives of Internal Medicine·Richard P AllenLuigi Ferini-Strambi
Feb 3, 2007·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Clete KushidaJohn E Ware
May 26, 2009·Sleep Medicine·Richard P AllenAndrew J Myers
Jul 8, 2011·Sleep Medicine Reviews·Kim E InnesParul Agarwal
Aug 24, 2011·Circulation·Brian B KooUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Group
Sep 22, 2011·Health and Quality of Life Outcomes·Hanna ScholzMagdolna Hornyak
Mar 27, 2012·BMJ Open·Anke C WinterTobias Kurth
Jul 4, 2012·Brain, Behavior, and Immunity·Lynn Marie TrottiDonald L Bliwise
Aug 16, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Michael J Howell, Carlos H Schenck
Nov 1, 2012·Blood Pressure Monitoring·Emine C ErdenMustafa Ozşahin
Apr 12, 2013·Psychosomatic Medicine·Andras SzentkiralyiKlaus Berger
May 7, 2013·Sleep Medicine·Marie-Hélène PennestriPaola A Lanfranchi
Jan 8, 2014·Sleep Medicine·Elena AntelmiFederica Provini
Feb 12, 2014·The Journal of Neuropsychiatry and Clinical Neurosciences·Hochang Benjamin LeeCynthia A Munro
Mar 7, 2014·Neurology·Chunbai ZhangXiang Gao
Oct 29, 2014·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Arthur S WaltersUNKNOWN MDS Committee on Rating Scales
Dec 17, 2014·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Andrea GalbiatiLuigi Ferini-Strambi
Feb 24, 2015·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Lynn Marie TrottiRonald D Chervin
Mar 10, 2015·Sleep Medicine·Rens HanewinckelM Arfan Ikram
Citations
Mar 8, 2018·Internal Medicine Journal·Michael X MaRoss Mac Nicholas
Aug 3, 2016·Clinical Medicine : Journal of the Royal College of Physicians of London·Lisa KlingelhoeferHeinz Reichmann
Feb 27, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jonathan Aseye NutakorOsei-Asibey Antwi
Jun 14, 2018·Frontiers in Neurology·Mónica M KurtisPablo Martinez-Martin
May 21, 2019·Journal of Clinical Pharmacology·Ningyuan ZhangQingshan Zheng
Oct 17, 2018·Frontiers in Neurology·Tayyabah YousafMarios Politis
Jan 9, 2019·Frontiers in Physiology·Viviana Lo MartireAlessandro Silvani
Sep 30, 2020·Medicine·Jie XiangMin Wang
May 28, 2020·International Journal of Environmental Research and Public Health·Giuseppe DidatoPaola Lanteri
Jun 20, 2017·Frontiers in Aging Neuroscience·Shiyi GuoTao Wang
Dec 22, 2020·Sleep Medicine·Jing GuoJianhua Sun
Dec 17, 2017·Journal of Pain and Symptom Management·Yuan-Yuan SongXiao-Lian Jiang
Apr 16, 2021·Anesthesia and Analgesia·Shelley Hershner, Dennis Auckley
Apr 27, 2021·Indian Journal of Psychiatry·Ridhima WadhwaRavi Gupta
Apr 6, 2020·Chest·Sofía Romero-PeraltaDiego García-Borreguero