Restoration of acetylcholinesterase activity by Euphorbia hirta in discrete brain regions of chronically stressed rats

Pharmaceutical Biology
H AnuradhaM Lakshmana

Abstract

Several drugs of herbal origin are known to possess anxiolytic and antidepressant effects. In a recent study, we showed that extracts from Euphorbia hirta L. (Euphorbiaceae) (Eh) demonstrated anxiolytic effects in rats subjected to chronic immobilization stress (CIS) but not in rats that underwent forced swim stress (FSS). Acetylcholine and the cholinergic system are known to be involved in anxiety. However, whether the cholinergic system is involved in the anxiolytic actions of Eh are not known. In the current study, we evaluated the effects of Eh treatment of rats subjected to either CIS or FSS on acetylcholinesterase (AChE) activity in the frontal cortex, hippocampus, and septum. CIS increased the AChE activity in all three regions, while Eh treatment restored it to normal levels. FSS increased the AChE activity only in the septum, and Eh treatment marginally restored this to normal levels. Thus, these results indicate the involvement of the cholinergic system in the behavioral effects of Euphorbia hirta.

References

Jul 6, 1993·European Journal of Pharmacology·J D BrioniM W Decker
Jun 9, 1998·Physiology & Behavior·R N McLayJ E Zadina
Apr 15, 2000·Pharmacology, Biochemistry, and Behavior·A VandenbogaerdeM Baraldi
Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·S E FileS Cheeta
Jul 19, 2001·Journal of Neural Transmission·H Sienkiewicz-JaroszA Płaźnik
Feb 4, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M R LampreaS Morato
Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·E A Carlini
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Oct 3, 2003·Neurobiology of Learning and Memory·Paul E Gold
Oct 6, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David O KennedyAndrew B Scholey
Aug 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Arvind GovindarajanSumantra Chattarji
Mar 30, 2007·Pharmacology, Biochemistry, and Behavior·Marilia BarrosCarlos Tomaz
Jul 20, 2007·Neuropeptides·S Johannes R RajaraoChad E Beyer

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