Restoration of action potential duration and transient outward current by regression of left ventricular hypertrophy

Journal of Molecular and Cellular Cardiology
H YokoshikiA Kitabatake

Abstract

The presence of left ventricular hypertrophy (LVH) is associated with an increased incidence of arrhythmias. Our previous study on hypertrophied rat hearts has demonstrated that regression of LVH prevents ischemia-induced lethal arrhythmias. To elucidate the underlying mechanism of the reduced incidence of arrhythmias in regression of LVH, we examined electrophysiological properties of both hypertrophied and regressed left ventricular cells. Hearts from spontaneously hypertensive rats (SHR) were used as LVH, and those from Wistar-Kyoto rats (WKY) served as control. SHR with regression of LVH (REG) was produced by captopril treatment. Action potentials and membrane currents of subendocardial left ventricular cells were compared by the whole-cell patch-clamp techniques. Although the membrane capacitance of SHR cells was significantly greater than that of WKY cells, that of REG cells was normalized to the control level. Prolonged action potential duration (APD) and reduced density of transient outward current (ito) in SHR cells was normalized by LVH regression (APD at 75% repolarization (ms) and ito density at +60 mV (pA/pF): WKY 36.1 +/- 4.2, 11.9 +/- 1.3, SHR 73.1 +/- 12.9, 5.2 +/- 0.7, REG 29.5 +/- 3.9, 10.4 +/- 2.0, P = 0.015,...Continue Reading

Citations

Jan 6, 2006·Pflügers Archiv : European journal of physiology·María Fernández-VelascoCarmen Delgado
Jun 11, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S E CrawfordC Mavroudis
Mar 23, 2004·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·David BellBarbara J McDermott
Feb 24, 2001·Journal of Hypertension·M G Hennersdorf, B E Strauer
Aug 15, 2000·Journal of Cardiovascular Pharmacology·V Nand, S A Doggrell
Feb 22, 2001·Journal of Molecular and Cellular Cardiology·E CerbaiA Mugelli
May 10, 2001·Journal of Molecular and Cellular Cardiology·G Y OuditP H Backx
May 15, 2002·The Journal of Pharmacy and Pharmacology·Sheila A Doggrell, Vinita Nand
Sep 9, 2016·Journal of Cardiovascular Medicine·Pasquale Pagliaro, Claudia Penna
Oct 5, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·S A Doggrell, V Nand
Jul 10, 2007·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Ljuba Bacharova
Aug 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Shoji SanadaMasafumi Kitakaze
Sep 16, 2006·The Journal of Pharmacology and Experimental Therapeutics·Adrian R AllenBarbara J McDermott
Oct 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Junichi ShimokawaHiroyuki Tsutsui
Aug 25, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Kazuya MizukamiHiroyuki Tsutsui
Dec 5, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Luiz Fernando Rodrigues JuniorJosé Hamilton Matheus Nascimento
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·C ChouabeR Bonvallet

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