Restoration of advanced spermatogenic cells in the experimentally regressed rat testis: quantitative relationship to testosterone concentration within the testis

Endocrinology
C A AwoniyiB R Zirkin

Abstract

We examined the effect of exogenously administered testosterone (T) on the quantitative restoration of advanced spermatogenic cells in adult rat testes rendered azoospermic by treating rats with polydimethylsiloxane (PDS) implants of T and estradiol (E). Experimental rats received PDS-TE implants for an initial 8-week period; control rats received empty implants. By 8 weeks of PDS-TE treatment, rats became severely oligospermic, and the T concentration within the seminiferous tubule fluid (STF) was reduced approximately 80% (from 57.8 ng/ml in controls to 9.6 ng/ml). After the initial 8-week PDS-TE treatment, PDS-TE implants were removed from one group of rats; a second group of PDS-TE-implanted rats received an additional PDS-T implant of 24 cm. Eight weeks after the removal of PDS-TE implants or the implantation of additional T, testis weight and numbers of advanced spermatogenic cells were restored to those of control rats. The STF T concentration 8 weeks after the removal of PDS-TE implants also was restored to that in control rats. In contrast, the STF T concentration increased to only 40% of control values in the rats that received an additional T implant. Despite this 60% reduction in T concentration compared to the cont...Continue Reading

Citations

May 16, 2002·BJU International·Hiroyuki TanakaS Kamidono
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·William H Walker
Mar 24, 2016·Molecular and Cellular Endocrinology·Kushaan DumasiaN H Balasinor
Aug 11, 2015·Cell Reports·Tony DeFalcoBlanche Capel
Feb 10, 2012·Spermatogenesis·William H Walker
Apr 2, 2014·Seminars in Cell & Developmental Biology·Stefan Schlatt, Jens Ehmcke
Mar 7, 2014·Seminars in Cell & Developmental Biology·Lee B Smith, William H Walker
Dec 6, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Leping YeRen-Shan Ge
Apr 7, 2006·Human Reproduction Update·Kati L Matthiesson, Robert I McLachlan
Jul 1, 1991·Toxicology and Industrial Health·E LeeT Fabel
Jan 25, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Sarah J Potter, Tony DeFalco

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