PMID: 18424592Apr 22, 2008Paper

Restoration of body energy reserves during refeeding in rats is dependent on both the intensity of energy restriction and the metabolic status at the onset of refeeding [corrected

The Journal of Nutrition
Jean-Patrice RobinRené Groscolas

Abstract

During starvation, after a short dynamic period of adaptation (phase I), a metabolic steady state is reached in which proteins are spared and lipids provide most of the energy expended [phase II (P2)]. However, protein breakdown increases dramatically once a lower threshold of body lipids is reached [phase III (P3)]. Body composition, energy intake, energy expenditure, and energy efficiency were determined in 8 groups of rats (fed, food-deprived up to P2 or P3 of starvation and refed for 3 d, 7 d, or until body mass restoration) to determine whether the kinetics of lipid and/or protein reserve recovery may be slowed down when refeeding occurs after the lipid threshold has been reached. Despite larger losses, P3 refed rats restored their body reserves as efficiently as those refed in P2. Whatever the nutritional status at the onset of refeeding, rehydration occurred first and hyperphagia played a more important role than hypometabolism in the restoration of the lost reserves. However, the pattern of body component gains was different during early refeeding. In P3 refed rats, body lipids were restored preferentially by significant contribution from endogenous lipid production. Thus, the extent of lipid depletion has important con...Continue Reading

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Citations

Oct 2, 2009·Journal of Clinical Biochemistry and Nutrition·Shinji TaiKoji Okamura
Nov 26, 2010·Journal of Veterinary Pharmacology and Therapeutics·K NewhallJ G Sherman
Jul 8, 2011·The British Journal of Nutrition·Aya MoriyaKatsumi Shibata
Apr 15, 2015·Frontiers in Neuroscience·Atsushi FukushimaToshiya Funabashi
Mar 19, 2015·Pflügers Archiv : European journal of physiology·Sung Ryul LeeJin Han
Nov 2, 2016·The Journal of Experimental Biology·Quentin SchullJean-Patrice Robin
Apr 13, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Rogerio G PedrosaJulio Tirapegui
Sep 15, 2011·Fundamental & Clinical Pharmacology·François ReichardtJean-Hervé Lignot
Sep 13, 2011·Physiology & Behavior·Li-Na ZhangJohn R Speakman
Jul 1, 2010·Obesity Research & Clinical Practice·Shinji TaiKoji Okamura

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