Restoration of calcium influx corrects membrane hyperexcitability in injured rat dorsal root ganglion neurons.

Anesthesia and Analgesia
Quinn HoganDamir Sapunar

Abstract

We have previously shown that a decrease of inward Ca(2+) flux (I(Ca)) across the sensory neuron plasmalemma, such as happens after axotomy, increases neuronal excitability. From this, we predicted that increasing I(Ca) in injured neurons should correct their hyperexcitability. The influence of increased or decreased I(Ca) upon membrane biophysical variables and excitability was determined during recording from A-type neurons in nondissociated dorsal root ganglia after spinal nerve ligation using an intracellular recording technique. When the bath Ca(2+) level was increased to promote I(Ca), the after-hyperpolarization was decreased and repetitive firing was suppressed, which also followed amplification of Ca(2+)-activated K(+) current with selective agents NS1619 and NS309. A decreased external bath Ca(2+) concentration had the opposite effects, similar to previous observations in uninjured neurons. These findings indicate that at least a part of the hyperexcitability of somatic sensory neurons after axotomy is attributable to diminished inward Ca(2+) flux, and that measures to restore I(Ca) may potentially be therapeutic for painful peripheral neuropathy.

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Citations

Aug 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qingbo TangQuinn H Hogan
Mar 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Geza GemesQuinn H Hogan
Jul 12, 2014·Cell and Tissue Research·Anna M Hagenston, Manuela Simonetti
Mar 20, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Elliot S Krames
Feb 21, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Andrew S KoopmeinersQuinn H Hogan
Aug 16, 2012·Journal of Neurochemistry·Tim HuchoHans-Hilger Ropers
Nov 3, 2009·The Journal of Comparative Neurology·Sanja Lovric KojundzicDamir Sapunar
Oct 30, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Elliot S Krames
Mar 27, 2015·ASN Neuro·Pengcheng HanJiong Shi
Jul 12, 2013·Journal of Neurophysiology·Renuka RamachandraKeith S Elmslie
Jun 4, 2014·The Journal of Pharmacology and Experimental Therapeutics·Bin PanHsiang-en Wu
Sep 4, 2015·Journal of Neurophysiology·Danielle SundtDavid B Jaffe
Feb 3, 2018·Pain Reports·Alfredo Manzano-García, Mohammed Gamal-Eltrabily
Jun 8, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Guoliang YuBin Pan
Aug 19, 2021·Physiological Reports·Michael BietRobert Dumaine

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